Copper (Cu) is an essential micronutrient for most organisms and serves mainly as a redox-
active catalytic centre in enzymes cycling between Cu+ and Cu 2+. Membrane transporters …

Trace metals are supplied to chemically‐defined media (CDM) for optimal Chinese hamster
ovary (CHO) cell culture performance during the production of monoclonal antibodies and …

Polypyridyl coordinating ligands are common in metal complexes used in medicinal
inorganic chemistry. These ligands possess intrinsic cytotoxicity, but detailed data on this …

Microbes have proven to be robust workhorses for the large-scale production of many
chemicals. Especially, high-value biochemicals (eg, natural pigments, unsaturated fatty …

Replacement of serum and increasing use of chemically defined media demands
optimisation of trace metal components for biomanufacturing applications. Trace metal …

Copper homeostasis is crucial for cellular physiology and development, and its
dysregulation leads to disease. The Menkes ATPase ATP7A plays a key role in copper …

It is well established that the metal content in Chinese hamster ovary (CHO) cell culture
media (CCM) greatly affects process productivity and critical quality attributes (CQAs) …

Dysregulated metal homeostasis is associated with many pathological conditions, including
arthritic diseases. Osteoarthritis and rheumatoid arthritis are the two most prevalent …

Drug-mediated correction of abnormal biological zinc homeostasis could provide new routes
to treating neurodegeneration, cancer, and viral infections. Designing therapeutics to …

Copper is an essential dietary micronutrient in humans for proper cell function; however, in
excess, it is toxic. The human cell line Caco-2 is popular as an in vitro model for intestinal …