The status of the theory and the main methods of implementation of preparative liquid
chromatography are reviewed. On the theory front, the focus has recently shifted. The theory …

In the 7 years after publishing the second edition of this book, both practical application as
well as theoretical research on preparative chromatography have progressed significantly …

Product specifications, regulatory constraints, and tight production schedules impose
considerable pressures on separation scientists in industry. The first edition of HPLC …

Reverse osmosis (RO) membrane technology is increasingly applied for the production of
potable water on a large scale. However, slightly acidic and unbuffered RO permeate can …

A new reverse osmosis (RO) permeate remineralization process combining ion exchange
resin and bipolar membrane electrodialysis (BMED) was developed. Its feasibility for …

A method using a model-based approach to design and optimize an ion-exchange step in a
protein purification process is proposed for the separation of IgG from a mixture containing …

Preparative chromatography, especially simulated moving bed (SMB) chromatography, is a
key technology for the separation of fine chemicals on a production scale. Most of the design …

The thermodynamic behavior of octreotide, a cyclic octapeptide with important
pharmaceutical functions, has been simulated under reversed-phase gradient elution …

A new equation of competitive isotherms was derived in the framework of the ideal adsorbed
solution (IAS) that predicts multisolute adsorption isotherms from single-solute isotherms …

Process development, optimisation and robustness analysis for chromatography
separations are often entirely based on experimental work and generic knowledge. The …