Lipogenesis inhibitors: therapeutic opportunities and challenges
B Batchuluun, SL Pinkosky, GR Steinberg - Nature Reviews Drug …, 2022 - nature.com
Fatty acids are essential for survival, acting as bioenergetic substrates, structural
components and signalling molecules. Given their vital role, cells have evolved mechanisms …
components and signalling molecules. Given their vital role, cells have evolved mechanisms …
Viral hijacking of cellular metabolism
This review discusses the current state of the viral metabolism field and gaps in knowledge
that will be important for future studies to investigate. We discuss metabolic rewiring caused …
that will be important for future studies to investigate. We discuss metabolic rewiring caused …
[HTML][HTML] Viral activation of cellular metabolism
EL Sanchez, M Lagunoff - Virology, 2015 - Elsevier
To ensure optimal environments for their replication and spread, viruses have evolved to
alter many host cell pathways. In the last decade, metabolomic studies have shown that …
alter many host cell pathways. In the last decade, metabolomic studies have shown that …
De novo lipogenesis in health and disease
F Ameer, L Scandiuzzi, S Hasnain, H Kalbacher… - Metabolism, 2014 - Elsevier
Background De novo lipogenesis (DNL) is a complex and highly regulated metabolic
pathway. In normal conditions DNL converts excess carbohydrate into fatty acids that are …
pathway. In normal conditions DNL converts excess carbohydrate into fatty acids that are …
Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis
Dengue virus (DENV) modifies cellular membranes to establish its sites of replication.
Although the 3D architecture of these structures has recently been described, little is known …
Although the 3D architecture of these structures has recently been described, little is known …
Distinct viral and mutational spectrum of endemic Burkitt lymphoma
F Abate, MR Ambrosio, L Mundo, MA Laginestra… - PLoS …, 2015 - journals.plos.org
Endemic Burkitt lymphoma (eBL) is primarily found in children in equatorial regions and
represents the first historical example of a virus-associated human malignancy. Although …
represents the first historical example of a virus-associated human malignancy. Although …
Interplay between lipid metabolism, lipid droplets, and DNA virus infections
MA Farías, B Diethelm-Varela, AJ Navarro, AM Kalergis… - Cells, 2022 - mdpi.com
Lipid droplets (LDs) are cellular organelles rich in neutral lipids such as triglycerides and
cholesterol esters that are coated by a phospholipid monolayer and associated proteins …
cholesterol esters that are coated by a phospholipid monolayer and associated proteins …
Epstein-Barr virus lytic infection contributes to lymphoproliferative disease in a SCID mouse model
GK Hong, ML Gulley, WH Feng, HJ Delecluse… - Journal of …, 2005 - Am Soc Microbiol
ABSTRACT Most Epstein-Barr virus (EBV)-positive tumor cells contain one of the latent
forms of viral infection. The role of lytic viral gene expression in EBV-associated …
forms of viral infection. The role of lytic viral gene expression in EBV-associated …
Global metabolic profiling of infection by an oncogenic virus: KSHV induces and requires lipogenesis for survival of latent infection
Like cancer cells, virally infected cells have dramatically altered metabolic requirements. We
analyzed global metabolic changes induced by latent infection with an oncogenic virus …
analyzed global metabolic changes induced by latent infection with an oncogenic virus …
Hallmarks of metabolic reprogramming and their role in viral pathogenesis
Metabolic reprogramming is a hallmark of cancer and has proven to be critical in viral
infections. Metabolic reprogramming provides the cell with energy and biomass for large …
infections. Metabolic reprogramming provides the cell with energy and biomass for large …