[HTML][HTML] Lin28 regulates cancer cell stemness for tumour progression

Z Lin, M Radaeva, A Cherkasov, X Dong - Cancers, 2022 - mdpi.com
Simple Summary Cancer stem cells (CSCs) are a small population of tumour cells bearing
stemness characteristics. They have been deemed as a root of cancer development and a …

Phenotypic plasticity-alternate transcriptional programs driving treatment resistant prostate cancer

JS Nanda, P Koganti, G Perri… - Critical Reviews™ in …, 2022 - dl.begellhouse.com
Androgen deprivation therapy (ADT) that antagonizes androgen receptor (AR) signaling has
made significant increases to overall survival of prostate cancer patients. However, ADT is …

miR-140-5p protects cartilage progenitor/stem cells from fate changes in knee osteoarthritis

Y Chen, H Huang, W Zhong, L Li, Y Lu, H Si - International …, 2023 - Elsevier
Cartilage progenitor/stem cells (CPCs) are promising seed cells for cartilage regeneration,
but their fate changes and regulatory mechanisms in osteoarthritis (OA) pathogenesis …

Injectable hydrogel harnessing foreskin mesenchymal stem cell-derived extracellular vesicles for treatment of chronic diabetic skin wounds

C Xu, JF Cao, Y Pei, Y Kim, H Moon, CQ Fan… - Journal of Controlled …, 2024 - Elsevier
Chronic skin wounds are a serious complication of diabetes with a high incidence rate,
which can lead to disability or even death. Previous studies have shown that mesenchymal …

YY1/miR-140-5p/Jagged1/Notch axis mediates cartilage progenitor/stem cells fate reprogramming in knee osteoarthritis

Y Chen, G Liao, T Ma, L Li, J Yang, B Shen… - International …, 2023 - Elsevier
Osteoarthritis is a multifactorial disease characterized by cartilage degeneration, while
cartilage progenitor/stem cells (CPCs) are responsible for endogenous cartilage repair …

Design, synthesis and activity evaluation of quinolinone derivatives as EZH2 inhibitors

J Cai, H You, X Qin, Y Wang, W Li - Bioorganic & Medicinal Chemistry …, 2024 - Elsevier
The enhancer of zeste homologue 2 (EZH2) is the core catalytic subunit of polycomb
repressive complex 2, which catalyzes lysine 27 methylation of histone H3. Herein, a series …

Reconstructing the lung stem cell niche in vitro

D Swami, J Aich, B Bisht, MK Paul - Advances in Stem Cells and their …, 2022 - Elsevier
Lungs are constantly exposed to a variety of environmental hazards and undergo injury. In
response to injury, a reservoir of lung stem cells undergoes rapid self-renewal, proliferation …