Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell
development and T memory formation and encompasses new functions in the regulation of …

Long-lived memory CD8+ T cells play important roles in tumor immunity. Studies over the
past two decades have identified four subsets of memory CD8+ T cells-central, effector, stem …

Tissue-resident memory T cells (TRM) maintain immunity in diverse sites as determined in
mouse models, whereas their establishment and role in human tissues have been difficult to …

Autoimmune vasculitis of the medium and large elastic arteries can cause blindness, stroke,
aortic arch syndrome, and aortic aneurysm. The disease is often refractory to …

The commonly existing cellular heterogeneity plays a critical role in biological processes
such as embryonic development, cell differentiation, and disease progress. Single‐cell …

Immune checkpoint inhibitors (ICIs) have displayed potential efficacy in triple-negative
breast cancer (TNBC) treatment, while only a minority of patients benefit from ICI therapy …

Innovative immunotherapies based on immune checkpoint targeting antibodies and
engineered T cells are transforming the way we approach cancer treatment. However …

Abstract CD4+ and CD8+ T lymphocytes mediate most of the adaptive immune response
against tumors. Naïve T lymphocytes specific for tumor antigens are primed in lymph nodes …

Galectins are a large family of carbohydrate binding proteins with members in nearly every
lineage of multicellular life. Through tandem and en-mass genome duplications, over 15 …

Abstract Characterization of functional T cell clusters is key to developing strategies for
immunotherapy and predicting clinical responses in leukemia. Here, single‐cell RNA …