Heritable predisposition is an important cause of cancer in children and adolescents.
Although a large number of cancer predisposition genes and their associated syndromes …

Oculocutaneous albinism is an autosomal recessive disease caused by the complete
absence or decrease of melanin biosynthesis in melanocytes. Due to the reduction or …

Ultraviolet radiation (UVR) has numerous effects on skin, including DNA damage, tanning,
vitamin D synthesis, carcinogenesis, and immunomodulation. Keratinocytes containing …

Due to the implementation of the Montreal Protocol, which has limited, and is now probably
reversing, the depletion of the stratospheric ozone layer, only modest increases in solar UV …

Oculocutaneous albinism (OCA) is a group of rare, inherited disorders associated with
reduced melanin biosynthesis. Clinical manifestations of the eight known subtypes of OCA …

Background Skin cancer is rare among Africans and albinism is an established risk for skin
cancer in this population. Ultraviolet radiation is highest at the equator and African albinos …

Cutaneous melanoma can be a most challenging neoplasm of high lethality, in part due to
its extreme heterogeneity and characteristic aggressive and invasive nature. Indeed, its …

Albinism is a group of rare inherited disorders arising from impairment of melanin
biosynthesis. The reduction of melanin synthesis leads to hypopigmentation of the skin and …

Albinism includes a group of inherited conditions that result in reduced melanin production.
It has been documented across the world, with a high frequency in sub-Saharan Africa …

Melanin provides a crucial filter for solar UV radiation and its genetically determined
variation influences both skin pigmentation and risk of cancer. Genetic evidence suggests …