A virtual patient simulation modeling the neural and perceptual effects of human visual cortical stimulation, from pulse trains to percepts

I Fine, GM Boynton - Scientific Reports, 2024 - nature.com
The field of cortical sight restoration prostheses is making rapid progress with three clinical
trials of visual cortical prostheses underway. However, as yet, we have only limited insight …

An in-silico framework for modeling optimal control of neural systems

B Rueckauer, M van Gerven - Frontiers in Neuroscience, 2023 - frontiersin.org
Introduction Brain-machine interfaces have reached an unprecedented capacity to measure
and drive activity in the brain, allowing restoration of impaired sensory, cognitive or motor …

Theoretical analysis of optogenetic spiking with ChRmine, bReaChES and CsChrimson-expressing neurons for retinal prostheses

H Bansal, N Gupta, S Roy - Journal of Neural Engineering, 2021 - iopscience.iop.org
Objective. Optogenetics has emerged as a promising technique for neural prosthetics,
especially retinal prostheses, with unprecedented spatiotemporal resolution. Newly …

Theoretical prediction of broadband ambient light optogenetic vision restoration with ChRmine and its mutants

H Bansal, G Pyari, S Roy - Scientific Reports, 2024 - nature.com
Vision restoration is one of the most promising applications of optogenetics. However, it is
limited due to the poor-sensitivity, slow-kinetics and narrow band absorption spectra of …

[PDF][PDF] Bridging model and experiment in systems neuroscience with Cleo: the Closed-Loop, Electrophysiology, and Optophysiology simulation testbed

KA Johnsen, NA Cruzado, ZC Menard, AA Willats… - bioRxiv, 2023 - scholar.archive.org
Recent advances in neurotechnology enable exciting new experiments, including novel
paradigms such as closed-loop optogenetic control that achieve powerful causal …

Optogenetic activation of visual thalamus generates artificial visual percepts

J Wang, H Azimi, Y Zhao, M Kaeser, PV Sánchez… - Elife, 2023 - elifesciences.org
The lateral geniculate nucleus (LGN), a retinotopic relay center where visual inputs from the
retina are processed and relayed to the visual cortex, has been proposed as a potential …

Bridging model and experiment in systems neuroscience with Cleo: the Closed-Loop, Electrophysiology, and Optophysiology simulation testbed

KA Johnsen, NA Cruzado, ZC Menard, AA Willats… - …, 2024 - pmc.ncbi.nlm.nih.gov
Systems neuroscience has experienced an explosion of new tools for reading and writing
neural activity, enabling exciting new experiments such as all-optical or closed-loop control …

Optogenetic stimulation recruits cortical neurons in a morphology-dependent manner

D Berling, L Baroni, A Chaffiol, G Gauvain, S Picaud… - bioRxiv, 2024 - biorxiv.org
Single-photon optogenetic stimulation is a crucial tool in neuroscience, enabling precise,
cell-type-specific modulation of neuronal circuits. Miniaturization of this technique in the form …

Iso-orientation bias of layer 2/3 connections: the unifying mechanism of spontaneous, visually and optogenetically driven V1 dynamics

T Rózsa, R Cagnol, J Antolík - bioRxiv, 2024 - biorxiv.org
Functionally specific long-range lateral connectivity in layer 2/3 of the primary visual cortex
(V1) supports the integration of visual information across visual space and shapes …

Optimal Control of Neural Systems

B Rueckauer, M van Gerven - bioRxiv, 2022 - biorxiv.org
Brain-machine interfaces have reached an unprecedented capacity to measure and drive
activity in the brain, allowing restoration of impaired sensory, cognitive or motor function …