Malaria is one of the most devastating infectious diseases of humans. It is problematic
clinically and economically as it prevails in poorer countries and regions, strongly hindering …

The deep evolutionary history of African populations, since the emergence of modern
humans more than 300,000 years ago, has resulted in high genetic diversity and …

Southern Africa is consistently placed as a potential region for the evolution of Homo
sapiens. We present genome sequences, up to 13x coverage, from seven ancient …

There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …

The tempo and mode of adaptive evolution determine how natural selection shapes patterns
of genetic diversity in DNA polymorphism data. While slow mutation‐limited adaptation …

The human genetic factors that affect resistance to infectious disease are poorly understood.
Here we report a genome-wide association study in 17,000 severe malaria cases and …

Modern humans inhabit a variety of environments and are exposed to a plethora of selective
pressures, leading to multiple genetic adaptations to local environmental conditions. These …

In the last three decades, genetic studies have played an increasingly important role in
exploring human history. They have helped to conclusively establish that anatomically …

For almost any given human-tropic virus, bacterium, fungus, or parasite, the clinical outcome
of primary infection is enormously variable, ranging from asymptomatic to lethal infection …

Background Recent data indicate that non-Plasmodium falciparum species may be more
prevalent than thought in sub-Saharan Africa. Although Plasmodium malariae, Plasmodium …