Macrophages are best known for their protective search and destroy functions against
invading microorganisms. These processes are commonly known as chemotaxis and …

Inappropriate chemokine/receptor expression or regulation is linked to many diseases,
especially those characterized by an excessive cellular infiltrate, such as rheumatoid arthritis …

Abstract Phosphoinositide 3-kinases (PI3K) have long been considered promising drug
targets for the treatment of inflammatory and autoimmune disorders as well as cancer and …

Directional migration moves cells rapidly between points, whereas random migration allows
cells to explore their local environments. We describe a Rac1 mechanism for determining …

Over the past two decades, new insights have positioned phosphoinositide 3-kinase-γ
(PI3Kγ) as a context-dependent modulator of immunity and inflammation. Recent advances …

We previously reported that extracellular ATP induces membrane ruffling and chemotaxis of
microglia and suggested that their induction is mediated by the Gi/o‐protein coupled P2Y12 …

Cell migration is essential for many biological processes in animals and is a complex highly
co‐ordinated process that involves cell polarization, actin‐driven protrusion and formation …

Leukocytes are key cellular components of innate immunity. These phagocytic cells respond
to bacteria at sites of infection through chemotactic sensing and directed motility regulated …

Numerous cell surface receptors, including tyrosine kinase and G protein‐coupled
receptors, play critical roles in endothelial cell function and blood vessel development …

Class IB phosphatidylinositol 3-kinase p110γ (PI3Kγ) has gained increasing attention as a
promising drug target for the treatment of inflammatory disease. Extensive target-validation …