The kidney maintains electrolyte, water, and acid-base balance, eliminates foreign and
waste compounds, regulates blood pressure, and secretes hormones. There are at least 16 …

The principal cell of the kidney collecting duct is one of the most highly regulated epithelial
cell types in vertebrates. The effects of hormonal, autocrine, and paracrine factors to regulate …

The ubiquitously expressed serum‐and glucocorticoid‐inducible kinase‐1 (SGK1) is
genomically regulated by cell stress (including cell shrinkage) and several hormones …

Glucocorticoid-induced leucine zipper (GILZ) is a dexamethasone-inducible gene that
mediates glucocorticoid (GC) actions in a variety of cell types, including many cells of …

Aldosterone is a major mineralocorticoid steroid hormone secreted by glomerulosa cells in
the adrenal cortex. It regulates a variety of physiological responses including those to …

Highlights•Genetic dissection of ENaC mediated sodium transport validate novel drug
targets.•Signaling pathways controlling ENaC activity identifies novel drug targets.• …

In tissues which express the mineralocorticoid receptor (MR), aldosterone modulates the
expression of membrane targets such as the subunits of the epithelial Na+ channel, in …

Aldosterone exerts profound effects on renal and cardiovascular physiology. In the kidney,
aldosterone acts to preserve electrolyte and acid-base balance in response to changes in …

Glucocorticoids play a pivotal role in the proliferation of osteoblasts, but the underlying
mechanism has not been successfully elucidated. In this report, we have investigated the …

Abstract Serum-and-glucocorticoid-inducible-kinase-1 (SGK1) is under regulation of several
hormones, mediators and cell stressors. More specifically, SGK1 expression is particularly …