[HTML][HTML] The role of alternative splicing in cancer: From oncogenesis to drug resistance
R Sciarrillo, A Wojtuszkiewicz, YG Assaraf… - Drug Resistance …, 2020 - Elsevier
Alternative splicing is a tightly regulated process whereby non-coding sequences of pre-
mRNA are removed and protein-coding segments are assembled in diverse combinations …
mRNA are removed and protein-coding segments are assembled in diverse combinations …
RNA splicing factors as oncoproteins and tumour suppressors
H Dvinge, E Kim, O Abdel-Wahab… - Nature Reviews Cancer, 2016 - nature.com
The recent genomic characterization of cancers has revealed recurrent somatic point
mutations and copy number changes affecting genes encoding RNA splicing factors. Initial …
mutations and copy number changes affecting genes encoding RNA splicing factors. Initial …
[HTML][HTML] Comprehensive analysis of alternative splicing across tumors from 8,705 patients
Our comprehensive analysis of alternative splicing across 32 The Cancer Genome Atlas
cancer types from 8,705 patients detects alternative splicing events and tumor variants by …
cancer types from 8,705 patients detects alternative splicing events and tumor variants by …
Full-length transcript characterization of SF3B1 mutation in chronic lymphocytic leukemia reveals downregulation of retained introns
AD Tang, CM Soulette, MJ van Baren, K Hart… - Nature …, 2020 - nature.com
While splicing changes caused by somatic mutations in SF3B1 are known, identifying full-
length isoform changes may better elucidate the functional consequences of these …
length isoform changes may better elucidate the functional consequences of these …
Chronic lymphocytic leukaemia: from genetics to treatment
F Bosch, R Dalla-Favera - Nature reviews Clinical oncology, 2019 - nature.com
Chronic lymphocytic leukaemia (CLL), the most frequent type of leukaemia in adults, is a
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …
lymphoproliferative disorder that is characterized by the expansion of monoclonal, mature …
Alternative‐splicing defects in cancer: splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics
LM Urbanski, N Leclair… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
Defects in alternative splicing are frequently found in human tumors and result either from
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …
mutations in splicing‐regulatory elements of specific cancer genes or from changes in the …
Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes
A Sveen, S Kilpinen, A Ruusulehto, RA Lothe… - Oncogene, 2016 - nature.com
Alternative splicing is a widespread process contributing to structural transcript variation and
proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both …
proteome diversity. In cancer, the splicing process is commonly disrupted, resulting in both …
Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial
S Stilgenbauer, A Schnaiter, P Paschka… - Blood, The Journal …, 2014 - ashpublications.org
Abstract Mutations in TP53, NOTCH1, and SF3B1 were analyzed in the CLL8 study
evaluating first-line therapy with fludarabine and cyclophosphamide (FC) or FC with …
evaluating first-line therapy with fludarabine and cyclophosphamide (FC) or FC with …
The molecular pathogenesis of chronic lymphocytic leukaemia
G Fabbri, R Dalla-Favera - Nature Reviews Cancer, 2016 - nature.com
Recent investigations have provided an increasingly complete picture of the genetic
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …
landscape of chronic lymphocytic leukaemia (CLL). These analyses revealed that the CLL …
Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3
Gene expression profiles and chromosome 3 copy number divide uveal melanomas into two
distinct classes correlating with prognosis,,. Using exome sequencing, we identified …
distinct classes correlating with prognosis,,. Using exome sequencing, we identified …