Prediction of post‐translational glycosylation and phosphorylation of proteins from the amino acid sequence
Post‐translational modifications (PTMs) occur on almost all proteins analyzed to date. The
function of a modified protein is often strongly affected by these modifications and therefore …
function of a modified protein is often strongly affected by these modifications and therefore …
Prediction of protein function from protein sequence and structure
JC Whisstock, AM Lesk - Quarterly reviews of biophysics, 2003 - cambridge.org
1. Introduction 3082. Plan of this article 3123. Natural mechanisms of development of novel
protein functions 3133.1 Divergence 3133.2 Recruitment 3163.3 'Mixing and matching'of …
protein functions 3133.1 Divergence 3133.2 Recruitment 3163.3 'Mixing and matching'of …
[HTML][HTML] The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens
N Zhou, Y Jiang, TR Bergquist, AJ Lee, BZ Kacsoh… - Genome biology, 2019 - Springer
Abstract Background The Critical Assessment of Functional Annotation (CAFA) is an
ongoing, global, community-driven effort to evaluate and improve the computational …
ongoing, global, community-driven effort to evaluate and improve the computational …
[HTML][HTML] A large-scale evaluation of computational protein function prediction
Automated annotation of protein function is challenging. As the number of sequenced
genomes rapidly grows, the overwhelming majority of protein products can only be …
genomes rapidly grows, the overwhelming majority of protein products can only be …
[图书][B] Deep learning in science
P Baldi - 2021 - books.google.com
This is the first rigorous, self-contained treatment of the theory of deep learning. Starting with
the foundations of the theory and building it up, this is essential reading for any scientists …
the foundations of the theory and building it up, this is essential reading for any scientists …
Contrastive learning on protein embeddings enlightens midnight zone
Experimental structures are leveraged through multiple sequence alignments, or more
generally through homology-based inference (HBI), facilitating the transfer of information …
generally through homology-based inference (HBI), facilitating the transfer of information …
Feature-based prediction of non-classical and leaderless protein secretion
We present a sequence-based method, SecretomeP, for the prediction of mammalian
secretory proteins targeted to the non-classical secretory pathway, ie proteins without an N …
secretory proteins targeted to the non-classical secretory pathway, ie proteins without an N …
[HTML][HTML] Protein disorder prediction: implications for structural proteomics
A great challenge in the proteomics and structural genomics era is to predict protein
structure and function, including identification of those proteins that are partially or wholly …
structure and function, including identification of those proteins that are partially or wholly …
Predicting subcellular localization of proteins for Gram‐negative bacteria by support vector machines based on n‐peptide compositions
Gram‐negative bacteria have five major subcellular localization sites: the cytoplasm, the
periplasm, the inner membrane, the outer membrane, and the extracellular space. The …
periplasm, the inner membrane, the outer membrane, and the extracellular space. The …
Distinguishing enzyme structures from non-enzymes without alignments
The ability to predict protein function from structure is becoming increasingly important as
the number of structures resolved is growing more rapidly than our capacity to study …
the number of structures resolved is growing more rapidly than our capacity to study …