DNA methylation provides a pivotal layer of epigenetic regulation in eukaryotes that has
significant involvement for numerous biological processes in health and disease. The …

Solid-state nanopores are nm sized apertures formed in thin synthetic membranes. These
single molecule sensors have been used in a variety of biophysical and diagnostic …

Methylation of cytosine bases in DNA provides a layer of epigenetic control in many
eukaryotes that has important implications for normal biology and disease. Therefore …

A striking feature of the human genome is the dearth of CpG dinucleotides (CpGs)
interrupted occasionally by CpG islands (CGIs), regions with relatively high content of the …

Cytosine methylation is required for mammalian development and is often perturbed in
human cancer. To determine how this epigenetic modification is distributed in the genomes …

Epigenetic alterations, such as abnormal DNA-methylation patterns, are associated with
many human tumour types. New techniques have been developed to perform genome-wide …

How breast cancers are able to disseminate and metastasize is poorly understood. Using a
hyperplasia transplant system, we show that tumor dissemination and metastasis occur in …

The development of cancer is driven by the accumulation of scores of alterations affecting
the structure and function of the genome. Equally important in this process are genetic …

Epigenomic studies aim to define the location and nature of the genomic sequences that are
epigenetically modified. Much progress has been made towards whole-genome epigenetic …

Background: Fetal DNA has been detected in maternal plasma by the use of genetic
differences between mother and fetus. We explore the possibility of using epigenetic …