An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis

X Ren, CM McHale, CF Skibola, AH Smith… - Environmental …, 2011 - ehp.niehs.nih.gov
Background Exposure to arsenic, an established human carcinogen, through consumption
of highly contaminated drinking water is a worldwide public health concern. Several …

[HTML][HTML] Chronic arsenic toxicity: studies in West Bengal, India

DG Mazumder, UB Dasgupta - The Kaohsiung journal of medical sciences, 2011 - Elsevier
Chronic arsenic toxicity (arsenicosis) as a result of drinking arsenic-contaminated
groundwater is a major environmental health hazard throughout the world, including India. A …

Molecular mechanisms of arsenic-induced disruption of DNA repair

LM Tam, NE Price, Y Wang - Chemical research in toxicology, 2020 - ACS Publications
Exposure to arsenic in contaminated drinking water is an emerging public health problem
that impacts more than 200 million people worldwide. Accumulating lines of evidence from …

Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes

H Zhong, J Beaulaurier, PY Lum, C Molony… - PLoS …, 2010 - journals.plos.org
Genome-wide association studies (GWAS) have demonstrated the ability to identify the
strongest causal common variants in complex human diseases. However, to date, the …

Effects of arsenic exposure on DNA methylation in cord blood samples from newborn babies and in a human lymphoblast cell line

P Intarasunanont, P Navasumrit, S Waraprasit… - Environmental …, 2012 - Springer
Background Accumulating evidence indicates that in utero exposure to arsenic is associated
with congenital defects and long-term disease consequences including cancers. Recent …

Epigenetic remodeling during arsenical-induced malignant transformation

TJ Jensen, P Novak, KE Eblin, AJ Gandolfi… - …, 2008 - academic.oup.com
Humans are exposed to arsenicals through many routes with the most common being in
drinking water. Exposure to arsenic has been associated with an increase in the incidence …

Chronic low-level arsenic exposure causes gender-specific alterations in locomotor activity, dopaminergic systems, and thioredoxin expression in mice

U Bardullas, JH Limón-Pacheco, M Giordano… - Toxicology and Applied …, 2009 - Elsevier
Arsenic (As) is a toxic metalloid widely present in the environment. Human exposure to As
has been associated with the development of skin and internal organ cancers and …

Toxicogenomics of arsenic: classical ideas and recent advances

P Ghosh, M Banerjee, AK Giri, K Ray - Mutation Research/Reviews in …, 2008 - Elsevier
Exposure to arsenic, a toxic metalloid distributed widely in nature, has been known to result
in hazardous health outcomes including cancer. Incidence of arsenic toxicity, mostly from …

Arsenic exposure induces genomic hypermethylation

S Majumdar, S Chanda, B Ganguli… - Environmental …, 2010 - Wiley Online Library
Gene‐specific hypermethylation has previously been detected in Arsenic exposed persons.
To monitor the level of whole genome methylation in persons exposed to different levels of …

Epigenetic mediated transcriptional activation of WNT5A participates in arsenical-associated malignant transformation

TJ Jensen, RJ Wozniak, KE Eblin, SM Wnek… - Toxicology and applied …, 2009 - Elsevier
Arsenic is a human carcinogen with exposure associated with cancer of the lung, skin, and
bladder. Many potential mechanisms have been implicated as playing a role in the process …