Integrating expert ODEs into neural ODEs: pharmacology and disease progression

Z Qian, W Zame, L Fleuren, P Elbers… - Advances in …, 2021 - proceedings.neurips.cc
Modeling a system's temporal behaviour in reaction to external stimuli is a fundamental
problem in many areas. Pure Machine Learning (ML) approaches often fail in the small …

Predictors for extubation failure in COVID-19 patients using a machine learning approach

LM Fleuren, TA Dam, M Tonutti, DP de Bruin… - Critical Care, 2021 - Springer
Introduction Determining the optimal timing for extubation can be challenging in the
intensive care. In this study, we aim to identify predictors for extubation failure in critically ill …

The Dutch Data Warehouse, a multicenter and full-admission electronic health records database for critically ill COVID-19 patients

LM Fleuren, TA Dam, M Tonutti, DP de Bruin… - Critical Care, 2021 - Springer
Abstract Background The Coronavirus disease 2019 (COVID-19) pandemic has underlined
the urgent need for reliable, multicenter, and full-admission intensive care data to advance …

Differences and similarities among COVID-19 patients treated in seven ICUs in three countries within one region: an observational cohort study

D Mesotten, DAM Meijs, BCT van Bussel… - Critical Care …, 2022 - journals.lww.com
OBJECTIVES: To investigate healthcare system–driven variation in general characteristics,
interventions, and outcomes in coronavirus disease 2019 (COVID-19) patients admitted to …

[HTML][HTML] Optimizing discharge after major surgery using an artificial intelligence–based decision support tool (DESIRE): An external validation study

D van de Sande, ME van Genderen, C Verhoef… - Surgery, 2022 - Elsevier
Background In the DESIRE study (Discharge aftEr Surgery usIng aRtificial intElligence), we
have previously developed and validated a machine learning concept in 1,677 …

[HTML][HTML] Assess and validate predictive performance of models for in-hospital mortality in COVID-19 patients: a retrospective cohort study in the Netherlands …

I Vagliano, MC Schut, A Abu-Hanna… - International Journal of …, 2022 - Elsevier
Purpose To assess, validate and compare the predictive performance of models for in-
hospital mortality of COVID-19 patients admitted to the intensive care unit (ICU) over two …

Modern learning from big data in critical care: primum non nocere

BY Gravesteijn, EW Steyerberg, HF Lingsma - Neurocritical Care, 2022 - Springer
Large and complex data sets are increasingly available for research in critical care. To
analyze these data, researchers use techniques commonly referred to as statistical learning …

Flexible serial capacity allocation with intensive care application

NM van Dijk, E van der Sluis, LN Bulder… - International Journal of …, 2024 - Elsevier
Serial delay structures are of natural and practical interest, as in production, communications
and health care. Flexible service allocation might well be beneficial, particularly to handle …

Risk factors for adverse outcomes during mechanical ventilation of 1152 COVID-19 patients: a multicenter machine learning study with highly granular data from the …

LM Fleuren, M Tonutti, DP de Bruin… - Intensive Care Medicine …, 2021 - Springer
Background The identification of risk factors for adverse outcomes and prolonged intensive
care unit (ICU) stay in COVID-19 patients is essential for prognostication, determining …

[HTML][HTML] Determining and assessing characteristics of data element names impacting the performance of annotation using Usagi

R de Groot, DP Püttmann, LM Fleuren, PJ Thoral… - International Journal of …, 2023 - Elsevier
Introduction Hospitals generate large amounts of data and this data is generally modeled
and labeled in a proprietary way, hampering its exchange and integration. Manually …