This map is an update of the edition 9 map by Berlyn et al.(MKB Berlyn, KB Low, and KE
Rudd, p. 1715–1902, in FC Neidhardt et al., ed., Escherichia coli and Salmonella: cellular …

One of the first hurdles to be negotiated in the postgenomic era involves the description of
the entire protein content of the cell, the proteome. Such efforts are presently complicated by …

Small interfering RNAs (siRNAs) are the mediators of mRNA degradation in the process of
RNA interference (RNAi). Here, we describe a human biochemical system that recapitulates …

The H/ACA small nucleolar RNAs (snoRNAs) are involved in pseudouridylation of pre-
rRNAs. In the yeast Saccharomyces cerevisiae, four common proteins are associated with …

Cellular RNA molecules contain phosphate or hydroxyl ends. A 2′, 3′-cyclic phosphate
(cP) is one of the 3′-terminal forms of RNAs mainly generated from RNA cleavage by …

Type I topoisomerases alter DNA topology by cleaving and rejoining one strand of duplex
DNA through a covalent protein–DNA intermediate. Here we show that vaccinia …

Current models of recombination between viral RNAs are based on replicative template-
switch mechanisms. The existence of nonreplicative RNA recombination in poliovirus is …

The discovery of discontiguous tRNA genes triggered studies dissecting the process of tRNA
splicing. As a result, we have gained detailed mechanistic knowledge on enzymatic removal …

Intron removal from tRNA precursors involves cleavage by a tRNA splicing endonuclease to
yield tRNA 3′-halves beginning with a 5′-hydroxyl, and 5′-halves ending in a 2′, 3 …

C16orf57 encodes a human protein of unknown function, and mutations in the gene occur in
poikiloderma with neutropenia (PN), which is a rare, autosomal recessive disease …