Nicotinamide phosphoribosyltransferase (NAMPT) is a regulator of the intracellular
nicotinamide adenine dinucleotide (NAD) pool. NAD is an essential coenzyme involved in …

Protein folding is a biophysical process by which proteins reach a specific three-dimensional
structure. The amino acid sequence of a polypeptide chain contains all the information …

Ferroptosis, a non-apoptotic form of programmed cell death, is triggered by oxidative stress
in cancer, heat stress in plants, and hemorrhagic stroke. A homeostatic transcriptional …

ADP-ribosylation of proteins is emerging as an important regulatory mechanism. Depending
on the family member, ADP-ribosyltransferases either conjugate a single ADP-ribose to a …

Abstract Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), initially identified as a
glycolytic enzyme and considered as a housekeeping gene, is widely used as an internal …

Abstract Poly (ADP-ribose) polymerases (PARPs) modify target proteins post-translationally
with poly (ADP-ribose)(PAR) or mono (ADP-ribose)(MAR) using NAD+ as substrate. The …

Major advances have recently defined functions for human mono-ADP-ribosylating PARP
enzymes (mono-ARTs), also opening up potential applications for targeting them to treat …

Proper and timely regulation of cellular processes is fundamental to the overall health and
viability of organisms across all kingdoms of life. Thus, organisms have evolved multiple …

Precisely controlling the activation of transcription factors is crucial for physiology. After a
transcription factor is activated and carries out its transcriptional activity, it also needs to be …

Immunotherapy has revolutionized the practice of oncology, improving survival in certain
groups of patients with cancer. Immunotherapy can synergize with radiation therapy …