Regulatory mechanisms of natural compounds from traditional Chinese herbal medicines on the microglial response in ischemic stroke

MH Ri, Y Xing, HX Zuo, MY Li, HL Jin, J Ma, X Jin - Phytomedicine, 2023 - Elsevier
Background Development of clinically effective neuroprotective agents for stroke therapy is
still a challenging task. Microglia play a critical role in brain injury and recovery after …

Mechanisms of ferroptotic and non-ferroptotic organ toxicity of chemotherapy: protective and therapeutic effects of ginger, 6-gingerol and zingerone in preclinical …

AC Famurewa, RE Akhigbe, MY George… - Naunyn-Schmiedeberg's …, 2024 - Springer
Chemotherapy (CT) is one of the flagship options for the treatment of cancers worldwide. It
involves the use of cytotoxic anticancer agents to kill or inhibit the proliferation of cancer …

Characterization of Eurotium cristatum Fermented Thinned Young Apple and Mechanisms Underlying Its Alleviating Impacts on Experimental Colitis

W Song, L Zhou, T Liu, G Wang, J Lv… - Journal of Agricultural …, 2024 - ACS Publications
A hundred million tons of young apples are thinned and discarded in the orchard per year,
aiming to increase the yield and quality of apples. We fermented thinned young apples …

Effect of galangin on oxidative stress, antioxidant defenses and mitochondrial dynamics in a rat model of focal cerebral ischemia

A Supawat, N Palachai, J Jittiwat - Biomedical Reports, 2024 - spandidos-publications.com
Focal ischemia occurs when a cerebral artery becomes obstructed by an embolus or
thrombus, leading to a rapid reduction in cerebral blood flow and significantly increasing the …

In vivo protective effects of 6‑gingerol in cerebral ischemia involve preservation of antioxidant defenses and activation of anti‑apoptotic pathways

R Kongsui, J Jittiwat - Biomedical Reports, 2024 - spandidos-publications.com
Stroke is an important medical problem in developing countries, characterized by a sudden
disruption of blood supply to the brain, either through occlusion or hemorrhage. It is a major …

[HTML][HTML] Palmitoylethanolamide (PEA) for Prevention of Gastroesophageal Inflammation: Insights from In Vitro Models

R Spigarelli, C Calabrese, E Spisni, S Vinciguerra… - Life, 2024 - mdpi.com
Gastroesophageal reflux disease (GERD) is a digestive disorder that can lead to chronic
mucosal damage, causing esophagitis, Barrett's esophagus and esophageal cancer. GERD …

Mercury chloride causes cognitive impairment, oxidative stress and neuroinflammation in male Wistar rats: The potential protective effect of 6-gingerol-rich fraction of …

AO Asuku, MT Ayinla, AJ Ajibare, TS Olajide - Brain Research, 2024 - Elsevier
This study investigated the effects of 6-gingerol-rich fraction of Zingiber officinale (6-
GIRIFZO) on mercury chloride (HgCl 2)-induced neurotoxicity in Wistar rats. Thirty-five male …

6‐gingerol effect on rat liver following exposure to gold nanoparticles: From histopathologic findings to inflammatory and oxidative stress biomarkers

F Fatemi, G Vaezi, S Sharafi… - Journal of Biochemical …, 2024 - Wiley Online Library
Gold nanoparticles (AuNPs) have unique features which could be beneficial to various
aspects of clinics and industry. Long‐term exposure to AuNPs damages the physiologic …

Therapeutic Effects of 6-Gingerol in Nerve Regeneration Following Sciatic Nerve Crush Injury: A Rat Model Study

HF Al-Saedi, HA Ghanimi, M Aal-Aaboda… - Regenerative …, 2024 - Springer
Purpose This study assesses the effects of 6-gingerol treatment on nerve regeneration in
male Wistar rats following sciatic nerve crushing. Method To induce injury, rats were …

[PDF][PDF] Neuroprotective Properties of the Aqueous and Ethanolic Extracts of Artocarpus heterophyllus (Jack Fruit) on the Cerebral Cortex and Hippocampus of Mercury …

OF Ovie, OK Chukwuemeka, N Charles… - nijournals.org
Mercuric chloride intoxication in rodents causes spatial learning and memory impairment.
The present study was carried out to investigate the possible protective role of jackfruit …