Our understanding of how cis-regulatory elements work has advanced rapidly, outpacing
our evolutionary models. In this review, we consider the implications of new mechanistic …

Transcription factors (TFs) intricately govern cellular processes and responses to external
stimuli by modulating gene expressions. TFs help plants to balance the trade-off between …

The development of multicellular organisms requires coordinated changes in gene
expression that are often mediated by the interaction between transcription factors (TFs) and …

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) is a transcription factor protein-coding
gene, considered a master regulator of the cellular stress response. The genetic variations …

The development of multi-cellular organisms requires coordinated changes in gene
expression that are often mediated by the interaction between transcription factors (TFs) and …

Sequence variation in enhancers that control cell-type-specific gene transcription
contributes significantly to phenotypic variation within human populations. However, it …

Abstract Background Transcription factors (TFs) exhibit heterogeneous DNA-binding
specificities in individual cells and whole organisms under natural conditions, and de novo …

Background Growing evidence suggests that distal regulatory elements are essential for
cellular function and states. The sequences within these distal elements, especially motifs …

Rheumatoid Arthritis (RA) is a chronic autoimmune disease characterized by severe joint
pain. There are conflicting results for the association of Interleukin 4 (IL4) variable number …

Microglia, the brain's resident macrophages, can be reconstituted by surrogate cells-a
process termed “microglia replacement.” To expand the microglia replacement toolkit, we …