Simple Summary MicroRNAs (miRNAs) have been under the spotlight for the last three
decades. These non-coding RNAs seem to be dynamic regulators of mRNA stability and …

T cell acute lymphoblastic leukemia (T-ALL) is a biologically and genetically heterogeneous
disease with a poor prognosis overall and several subtypes. The neoplastic transformation …

Acute lymphoblastic leukemia (ALL) is the most prevalent cancer among children, and
multidrug efflux mediated by overexpression of ABC transporters is the major impediment to …

Multidrug resistance (MDR) is considered as the major obstacle for treating pediatric acute
lymphoblastic leukemia (ALL). MicroRNAs (miRNAs) are small non coding RNAs which may …

Background: Glioblastoma (GBM) is the most common primary malignant brain tumor in
adults. It is highly resistant to chemotherapy, and tumor recurrence is common. Neuronal …

Breast cancer is the second leading cause of morbidity and mortality in women worldwide.
Despite advancements in the clinical application of neoadjuvant chemotherapy (NAC), drug …

For decades, cancer biology focused largely on the protein-encoding genes that have clear
roles in tumor development or progression: cell-cycle control, apoptotic evasion, genome …

Iron metabolism are frequently disrupted in cancer. Patients with cancer are prone to anemia
and receive transfusions frequently; the condition which results in iron overload, contributing …

Background: MicroRNAs (miRNAs) participate in gene regulation and the control of cancer-
related mechanisms such as apoptosis, invasion and differentiation. Single nucleotide …

Background Relapse remains a critical challenge in children with acute lymphoblastic
leukemia (ALL). The emergence of immunoregulatory cells, including myeloid-derived …