Apart from having been used and misused for at least four millennia for, among others,
recreational and medicinal purposes, the cannabis plant and its most peculiar chemical …

Astrocytes are highly complex cells with many emerging putative roles in brain function. Of
these, gliotransmission (active information transfer from glia to neurons) has probably the …

Endocannabinoids are key modulators of synaptic function. By activating cannabinoid
receptors expressed in the central nervous system, these lipid messengers can regulate …

Despite being regarded as a hippie science for decades, cannabinoid research has finally
found its well-deserved position in mainstream neuroscience. A series of groundbreaking …

Dopamine plays a critical role in motor control, addiction, and reward-seeking behaviors,
and its release dynamics have traditionally been linked to changes in midbrain dopamine …

Major depression and anxiety disorders have high prevalence rates and are frequently
comorbid. The neurobiological bases for these disorders are not fully understood, and …

Highlights•Modulation of synaptic strength can occur through changes in short-term
plasticity.•Modulators can shape or induce long-term synaptic plasticity.•Modulators can …

Among the many signalling lipids, endocannabinoids are increasingly recognized for their
important roles in neuronal and glial development. Recent experimental evidence suggests …

Nitric oxide (NO) is an important signaling molecule that is widely used in the nervous
system. With recognition of its roles in synaptic plasticity (long-term potentiation, LTP; long …

The transient receptor potential TRPV1 is a nonselective cation channel that mediates pain
sensations and is commonly activated by a wide variety of exogenous and endogenous …