The accurate determination of a large number of protein structures by X-ray crystallography
makes it possible to conduct a reliable statistical analysis of the distribution of the main …

Background A large number of studies have been carried out to obtain amino acid
propensities for α-helices and β-sheets. The obtained propensities for α-helices are …

The molecular flexibility of proteins is a crucial factor in determining their biological
activity,[1] including binding affinity,[2] antigenicity,[3] and enzymatic activity.[4] The …

Background: The mitochondrial DNA (mtDNA) depletion syndrome (MDS) is an autosomal
recessive disorder of early childhood characterized by decreased mtDNA copy number in …

Perturbing the structure of the Pin1 WW domain, a 34‐residue protein comprised of three β‐
strands and two intervening loops has provided significant insight into the structural and …

Characterizing structures of protein complexes and their disease-related aberrations is
essential to understanding molecular mechanisms of many biological processes …

To study the effect of O‐glycosylation on the conformational propensities of a peptide
backbone, a 20‐residue peptide (GSTAPPAHGVTSAPDTRPAP) representing the full length …

Although streptavidin's high affinity for biotin has made it a widely used and studied binding
protein and labeling tool, its tetrameric structure may interfere with some assays. A …

A single residue in the ATP binding pocket of protein kinases—termed the gatekeeper—has
been shown to control sensitivity to a wide range of small molecule inhibitors (Chem. Biol …

Vibrational Raman optical activity (ROA) spectra of the wheat proteins α-gliadin (A-gliadin),
ω-gliadin, and a 30 kDa peptide called TA-1 from the high molecular weight glutenin subunit …