Fighting against skin aging: the way from bench to bedside

S Zhang, E Duan - Cell transplantation, 2018 - journals.sagepub.com
As the most voluminous organ of the body that is exposed to the outer environment, the skin
suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features …

Drug repurposing for rare diseases

HI Roessler, NVAM Knoers, MM van Haelst… - Trends in …, 2021 - cell.com
Currently, there are about 7000 identified rare diseases, together affecting 10% of the
population. However, fewer than 6% of all rare diseases have an approved treatment option …

In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice

LW Koblan, MR Erdos, C Wilson, WA Cabral, JM Levy… - Nature, 2021 - nature.com
Hutchinson–Gilford progeria syndrome (HGPS or progeria) is typically caused by a
dominant-negative C• G-to-T• A mutation (c. 1824 C> T; p. G608G) in LMNA, the gene that …

Molecular pathology of laminopathies

JY Shin, HJ Worman - Annual Review of Pathology …, 2022 - annualreviews.org
The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear
pore complexes. Laminopathies are diseases caused by mutations in genes encoding …

Protein lipidation: occurrence, mechanisms, biological functions, and enabling technologies

H Jiang, X Zhang, X Chen, P Aramsangtienchai… - Chemical …, 2018 - ACS Publications
Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …

Vascular stiffness in aging and disease

SF Vatner, J Zhang, C Vyzas, K Mishra… - Frontiers in …, 2021 - frontiersin.org
The goal of this review is to provide further understanding of increased vascular stiffness
with aging, and how it contributes to the adverse effects of major human diseases …

Post-translational modifications of intermediate filament proteins: mechanisms and functions

NT Snider, MB Omary - Nature reviews Molecular cell biology, 2014 - nature.com
Intermediate filaments (IFs) are cytoskeletal and nucleoskeletal structures that provide
mechanical and stress-coping resilience to cells, contribute to subcellular and tissue-specific …

Lonafarnib: first approval

S Dhillon - Drugs, 2021 - Springer
Lonafarnib (Zokinvy™) is an orally active farnesyltransferase inhibitor developed by Eiger
BioPharmaceuticals under license from Merck & Co. for the treatment of hepatitis D virus …

Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations

S Gonzalo, R Kreienkamp, P Askjaer - Ageing research reviews, 2017 - Elsevier
Products of the LMNA gene, primarily lamin A and C, are key components of the nuclear
lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is …

Oral prenylation inhibition with lonafarnib in chronic hepatitis D infection: a proof-of-concept randomised, double-blind, placebo-controlled phase 2A trial

C Koh, L Canini, H Dahari, X Zhao… - The Lancet Infectious …, 2015 - thelancet.com
Background Therapies for chronic hepatitis delta virus (HDV) infection are unsatisfactory.
Prenylation is essential for HDV and inhibition abrogates HDV production in experimental …