Toxins and venom components that target voltage-gated sodium (Na V) channels have
evolved numerous times due to the importance of this class of ion channels in the normal …

Animal venoms are a rich and complex source of components, including peptides (such as
neurotoxins, anionic peptides and hypotensins), lipids, proteins (such as proteases …

The recent publication of high-throughput transcriptomic and proteomic analyses of scorpion
venom glands has increased our knowledge on the biodiversity of venom components. In …

Ts17 was purified from the venom of the scorpion Tityus serrulatus, the most dangerous
scorpion species in Brazil. The activity on Na v 1.1-Na v 1.7 channels was …

Abstract Kv1. 3 K+ channels play a central role in the regulation of T cell activation and Ca
2+ signaling under physiological and pathophysiological conditions. Peptide toxins targeting …

Scorpion venom is an unmatched source of selective high-affinity ligands of potassium
channels. There is a high demand for such compounds to identify and manipulate the …

Scorpion venoms are known as a rich mixture of components, including peptides that can
interact with different ion channels, particularly voltage-gated potassium channels (Kv) …

BmK AEP, a scorpion peptide purified form the venom of Buthus martensii Karsch, has been
reported to display anti-epileptic activity. Voltage-gated sodium channels (VGSCs) are …

To1, previously named Tc49b, is a peptide neurotoxin isolated from venom of the scorpion
Tityus obscurus that is responsible for lethal human poisoning cases in the Brazilian …

Buthus martensii Karsch (Bm K), is a kind of traditional Chinese medicine, which has been
used for a long history for the treatment of many diseases, such as inflammation, pain and …