Mutational processes that alter large genomic regions occur frequently in developing
tumors. They range from simple copy number gains and losses to the shattering and …

Breast cancer is the most common cancer among women globally. Genomic instability (GI)
refers to the increased tendency to accrue genomic alterations. It drives heterogeneity and is …

Previously, we identified long repeat sequences that are frequently associated with genome
rearrangements, including copy number variation (CNV), in many diverse isolates of the …

HER2-positive breast cancer has long proven to be a clinically distinct class of breast
cancers for which several targeted therapies are now available. However, resistance to the …

Barrett's esophagus is a pre-malignant lesion that can progress to esophageal
adenocarcinoma. We perform a multi-omic analysis of pre-cancer samples from 146 patients …

Inverted duplications, also known as foldback inversions, are commonly observed in
cancers and are the major class of chromosome rearrangement recovered from yeast cells …

Background Adaptation of mammals to terrestrial life was facilitated by the unique vertebrate
trait of body hair, which occurs in a range of morphological patterns. Keratin associated …

Foldback priming at DNA double-stranded breaks is one mechanism proposed to initiate
palindromic gene amplification, a common feature of cancer cells. Here, we show that small …

Simple Summary Precise identification and annotation of mutations are of utmost importance
in clinical oncology. Insights of the DNA sequence can provide meaningful knowledge to …

Somatic copy-number alterations (SCNAs) are an important type of structural variation
affecting tumor pathogenesis. Accurate detection of genomic regions with SCNAs is crucial …