Hypertrophic cardiomyopathy (HCM) was traditionally described as an autosomal dominant
Mendelian disease but is now increasingly recognized as having a complex genetic …

Inherited cardiomyopathies are a major cause of mortality and morbidity worldwide and can
be caused by mutations in a wide range of proteins located in different cellular …

Background Obesity associated type 2 diabetes mellitus is a metabolic disorder; however,
the etiology of obesity associated type 2 diabetes mellitus remains largely unknown. There …

Background FLNC is one of the few genes associated with all types of cardiomyopathies, but
it also underlies neuromuscular phenotype. The combination of concomitant neuromuscular …

Discrete categorization of Mendelian disease genes into dominant and recessive models
often oversimplifies their underlying genetic architecture. Cardiomyopathies (CMs) are …

Hypertrophic cardiomyopathy (HCM) is one of the most common hereditary diseases, and it
is associated with fatal complications. The clinical heterogeneity of HCM requires risk …

Atrial fibrillation (AF) represents the most common type of clinical cardiac arrhythmia and
substantially increases the risks of cerebral stroke, heart failure and death. Accumulating …

Introduction: Sudden cardiac death (SCD) and early onset cardiomyopathy (CM) in the
young will always lead to suspicion of an underlying genetic disorder. Incited by the rapid …

Muscle atrophy due to colorectal cancer severely reduces the quality of life and survival time
of patients. However, the underlying causative mechanisms and therapeutic agents are not …

RBM20 (RNA-binding motif protein 20) is a splicing factor targeting multiple cardiac genes,
and its mutations cause cardiomyopathies. Originally, RBM20 mutations were discovered to …