The cardiovascular system plays a key role in sepsis, and septic myocardial depression is a
common finding associated with increased morbidity and mortality. Myocardial depression …

Septic shock, the most severe complication of sepsis, accounts for∼ 10% of all admissions
to intensive care. Our understanding of its complex pathophysiology remains incomplete but …

Background To determine whether a restrictive strategy of red-cell transfusion and a liberal
strategy produced equivalent results in critically ill patients, we compared the rates of death …

Background Elevation of systemic oxygen delivery and consumption has been associated
with an improved outcome in critically ill patients. We conducted a randomized trial to …

Background Some observational studies suggest that the use of pulmonary-artery catheters
to guide therapy is associated with increased mortality. Methods We performed a …

Intravenous fluids are widely administered to patients who have, or are at risk of, acute
kidney injury (AKI). However, deleterious consequences of overzealous fluid therapy are …

After several decades of intensive efforts, safe injectable preparations capable of effectively
delivering O2 to tissues and removing CO2, ie, so-called blood substitutes, appear to be …

Organ dysfunction and multiple organ failure are the main causes of prolonged hospital stay
after cardiac surgery, which increases resource use and health care costs. Increased levels …

STUDY OBJECTIVE: To study early microcirculatory perfusion indices in patients with
severe sepsis/septic shock, compare early microcirculatory indices in sepsis survivors …

Blood transfusion and blood conservation (techniques or strategies to avoid the need for
blood) are complementary activities that constitute the clinical arena of transfusion medicine …