Impact of trifluoromethyl and sulfonyl groups on the biological activity of novel aryl-urea derivatives: Synthesis, in-vitro, in-silico and SAR studies
We designed and prepared a novel series of urea derivatives with/without sulfonyl group in
their structures to investigate the impact of the sulfonyl group on the biological activity of the …
their structures to investigate the impact of the sulfonyl group on the biological activity of the …
Synthesis and biological evaluation of new 1, 3, 4-thiadiazole derivatives as potent antimicrobial agents
Abstract A series of 1, 3, 4-thiadiazole derivatives were designed and synthesized using N-
(4-nitrophenyl) acetohydrazonoyl bromide and 1-[3, 5-dimethyl-1-(4-nitrophenyl)-1 H …
(4-nitrophenyl) acetohydrazonoyl bromide and 1-[3, 5-dimethyl-1-(4-nitrophenyl)-1 H …
Biogenic selenium nanoparticles and selenium/chitosan-Nanoconjugate biosynthesized by Streptomyces parvulus MAR4 with antimicrobial and anticancer potential
Background As antibiotics and chemotherapeutics are no longer as efficient as they once
were, multidrug resistant (MDR) pathogens and cancer are presently considered as two of …
were, multidrug resistant (MDR) pathogens and cancer are presently considered as two of …
Synthesis, anticancer evaluation of novel hybrid pyrazole-based chalcones, molecular docking, DNA fragmentation, and gene expression: in vitro studies
A unique series of pyrazolyl-chalcone derivatives was synthesized via the method of Claisen–
Schmidt condensation. The desired chalcone derivatives 7a–d and 9a–f were obtained in …
Schmidt condensation. The desired chalcone derivatives 7a–d and 9a–f were obtained in …
[HTML][HTML] Cytotoxic urea Schiff base complexes for multidrug discovery as anticancer activity and low in vivo oral assessing toxicity
LM Aroua, AN Al-Hakimi, MAM Abdulghani… - Arabian Journal of …, 2022 - Elsevier
Novel mononuclear complexes 2–8 derived from hybrid Urea Schiff base HL were
synthesized using various metal Ni 2+, Fe 3+, Cu 2+, Co 2+, Mn 2+, Zn 2+, and Cr 3+. The …
synthesized using various metal Ni 2+, Fe 3+, Cu 2+, Co 2+, Mn 2+, Zn 2+, and Cr 3+. The …
Green, facile synthesis and evaluation of unsymmetrical carbamide derivatives as antimicrobial and anticancer agents with mechanistic insights
FM Sroor, AAF Soliman, EM Youssef, M Abdelraof… - Scientific Reports, 2024 - nature.com
A very practical method for the synthesis of unsymmetrical carbamide derivatives in good to
excellent yield was presented, without the need for any catalyst and at room temperature …
excellent yield was presented, without the need for any catalyst and at room temperature …
New 2, 4-diaryl-3-azabicyclo [3.3. 1] nonan-9-one derivatives as antimicrobial and anti-cancer agents: synthesis, in-vitro and SAR studies
A new series of biologically active 2, 4-diphenyl-N-(4-(thiophen-2-yl) thiazol-2-yl)-3-
azabicyclo [3.3. 1] nonan-9-imine and N-(4-(naphthalen-2-yl) thiazol-2-yl)-2, 4-diphenyl-3 …
azabicyclo [3.3. 1] nonan-9-imine and N-(4-(naphthalen-2-yl) thiazol-2-yl)-2, 4-diphenyl-3 …
Design, synthesis and in‐vitro evaluation of new furan‐substituted thiadiazolyl hydrazone derivatives as promising antimicrobial agents
Seventeen new furan‐substituted thiadiazolyl hydrazone derivatives bearing 4‐nitrophenyl
moiety were designed, synthesized and tested for their in vitro antimicrobial activity …
moiety were designed, synthesized and tested for their in vitro antimicrobial activity …
Design, synthesis, in vitro anticancer, molecular docking and SAR studies of new series of pyrrolo[2,3-d]pyrimidine derivatives
FM Sroor, WM Tohamy, KMA Zoheir, NM Abdelazeem… - BMC chemistry, 2023 - Springer
The current study involves the design and synthesis of a newly synthesized pyrrolo [2, 3-d]
pyrimidine derivatives to contain chlorine atoms in positions 4 and 6 and trichloromethyl …
pyrimidine derivatives to contain chlorine atoms in positions 4 and 6 and trichloromethyl …
A facile and robust approach for synthesis and structural characterization of an unprecedented ring system of 4H-pyrazolo [3, 4-f] indolizine-4, 9 (2H)-dione derivatives
FM Sroor, SS Mukhtar, TS Hafez, WM Tohamy… - Tetrahedron, 2023 - Elsevier
A facile and efficient route for the synthesis of novel 4H-pyrazolo [3, 4-f] indolizine-4, 9 (2H)-
dione derivatives was investigated and confirmed as a robust method. 2-Acetyl pyrrole was …
dione derivatives was investigated and confirmed as a robust method. 2-Acetyl pyrrole was …