Receptor tyrosine kinases (RTKs) play an important role in a variety of cellular processes
including growth, motility, differentiation, and metabolism. As such, dysregulation of RTK …

Glioblastoma (WHO grade IV astrocytoma) is the most frequent primary brain tumor in adults,
representing a highly heterogeneous group of neoplasms that are among the most …

Glioblastoma (GBM) is a primary neuroepithelial tumor of the central nervous system,
characterized by an extremely aggressive clinical phenotype. Patients with GBM have a …

We have extended our understanding of the molecular biology that underlies adult
glioblastoma over many years. By contrast, high-grade gliomas in children and adolescents …

Malignant astrocytic gliomas such as glioblastoma are the most common and lethal
intracranial tumors. These cancers exhibit a relentless malignant progression characterized …

Glioblastoma (GBM) is one of the most lethal human cancers. Genomic analyses are
defining the molecular architecture of GBM, uncovering relevant subsets of patients whose …

High-grade gliomas (HGGs) account for the vast majority of all gliomas, including
glioblastoma (World Health Organization (WHO) grade IV) and anaplasticgliomas (WHO …

Glioblastomas are heterogeneous neoplasms that are driven by complex signalling
pathways, and are among the most aggressive and challenging cancers to treat. Despite …

Glioblastoma multiforme (GBM) is the most common brain tumour and has the worst
prognosis. Epidermal growth factor receptor (EGFR) gene amplification, mutation and re …

Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein and a member of
the tyrosine kinase superfamily receptor. Gliomas are tumors originating from glial cells …