The hallmark of most cardiac diseases is the progressive loss of cardiomyocytes. In the
perinatal period, cardiomyocytes still proliferate, and the heart shows the capacity to …

DNA replication during cell proliferation is 'vertical'copying, which reproduces an initial
amount of genetic information. Polyploidy, which results from whole-genome duplication, is …

Gene regulatory divergence is thought to play a central role in determining human-specific
traits. However, our ability to link divergent regulation to divergent phenotypes is limited …

In spite of significant advancements of therapies for initial eradication of cancers, tumor
relapse remains a major challenge. It is for a long time known that polyploid malignant cells …

Using meta-analyses, we introduce a unicellular attractor (UCA) model integrating essential
features of the 'atavistic reversal','cancer attractor','somatic mutation','genome chaos', and …

Complex tissue regeneration is extremely rare among adult mammals. An exception,
however, is the superior tissue healing of multiple organs in spiny mice (Acomys). While …

Hepatocytes are the primary functional cells of the liver that perform essential roles in
homeostasis, regeneration, and injury. Most mammalian somatic cells are diploid and …

Single-cell transcriptomics enables inference of context-dependent phenotypes of individual
cells and determination of cellular diversity of complex tissues. Cardiac fibrosis is a leading …

A major objective of modern biomedical research aims to promote tissue self-regeneration
after injury, obviating the need for whole organ transplantation and avoiding mortality due to …

Abstract Whole-genome duplication (WGD), or polyploidy, increases the amount of genetic
information in the cell. WGDs of whole organisms are found in all branches of eukaryotes …