Phages for phage therapy: isolation, characterization, and host range breadth

P Hyman - Pharmaceuticals, 2019 - mdpi.com
For a bacteriophage to be useful for phage therapy it must be both isolated from the
environment and shown to have certain characteristics beyond just killing strains of the …

Clinical indications and compassionate use of phage therapy: personal experience and literature review with a focus on osteoarticular infections

O Patey, S McCallin, H Mazure, M Liddle, A Smithyman… - Viruses, 2018 - mdpi.com
The history of phage therapy started with its first clinical application in 1919 and continues its
development to this day. Phages continue to lack any market approval in Western medicine …

Bacteriophage T4 Infection of Stationary Phase E. coli: Life after Log from a Phage Perspective

D Bryan, A El-Shibiny, Z Hobbs, J Porter… - Frontiers in …, 2016 - frontiersin.org
Virtually all studies of phage infections investigate bacteria growing exponentially in rich
media. In nature, however, phages largely encounter non-growing cells. Bacteria entering …

A century of clinical use of phages: a literature review

K Diallo, A Dublanchet - Antibiotics, 2023 - mdpi.com
Growing antibiotic resistance and the broken antibiotic market have renewed interest in the
use of phages, a century-old therapy that fell into oblivion in the West after two decades of …

Phage therapy in a 16-year-old boy with Netherton syndrome

P Zhvania, NS Hoyle, L Nadareishvili… - Frontiers in …, 2017 - frontiersin.org
Netherton syndrome (NS) is a rare autosomal recessive disorder, characterized by a
classical triad of clinical features, including congenital ichthyosiform erythroderma …

Production of inhalation phage powders using spray freeze drying and spray drying techniques for treatment of respiratory infections

SSY Leung, T Parumasivam, FG Gao, NB Carrigy… - Pharmaceutical …, 2016 - Springer
Purpose The potential of aerosol phage therapy for treating lung infections has been
demonstrated in animal models and clinical studies. This work compared the performance of …

Re-establishing a place for phage therapy in western medicine

EM Kutter, SJ Kuhl, ST Abedon - Future microbiology, 2015 - Taylor & Francis
Use of bacterial viruses as antibacterial agents has a history nearly as long as the now 100-
year study of bacteriophages. Therapeutic phages are especially useful in the absence of …

Approaches to optimize therapeutic bacteriophage and bacteriophage-derived products to combat bacterial infections

M Reuter, DH Kruger - Virus Genes, 2020 - Springer
The emerging occurrence of antibiotic-resistant bacterial pathogens leads to a recollection
of bacteriophage as antimicrobial therapeutics. This article presents a short overview of the …

Phage therapy in the era of synthetic biology

EM Barbu, KC Cady, B Hubby - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
For more than a century, bacteriophage (or phage) research has enabled some of the most
important discoveries in biological sciences and has equipped scientists with many of the …

Bacteriophage clinical use as antibacterial “drugs”: utility and precedent

ST Abedon - Bugs as Drugs: Therapeutic Microbes for the …, 2018 - Wiley Online Library
Phage therapy is the use of bacterial viruses to reduce or eliminate bacterial infections. As
such, phage therapy has been employed clinically for approximately 100 years. It is …