[HTML][HTML] Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy

Y Iwakiri, J Trebicka - JHEP reports, 2021 - Elsevier
Portal hypertension, defined as increased pressure in the portal vein, develops as a
consequence of increased intrahepatic vascular resistance due to the dysregulation of liver …

Primary Budd–Chiari Syndrome

JC Garcia-Pagán, DC Valla - New England Journal of Medicine, 2023 - Mass Medical Soc
Primary Budd–Chiari Syndrome | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

[HTML][HTML] Evolution in the understanding of the pathophysiological basis of portal hypertension: how changes in paradigm are leading to successful new treatments

J Bosch, RJ Groszmann, VH Shah - Journal of hepatology, 2015 - Elsevier
Among the common complication of cirrhosis portal hypertension witnessed a major
improvement of prognosis during the past decades. Principally due to the introduction of …

Non-invasive evaluation of portal hypertension using ultrasound elastography

A Berzigotti - Journal of hepatology, 2017 - Elsevier
Portal hypertension (PH) leads to serious complications, such as bleeding from
gastroesophageal varices, ascites and portosystemic encephalopathy in patients with …

Mechanical stretch increases expression of CXCL1 in liver sinusoidal endothelial cells to recruit neutrophils, generate sinusoidal microthombi, and promote portal …

MB Hilscher, T Sehrawat, JP Arab, Z Zeng, J Gao… - Gastroenterology, 2019 - Elsevier
Background & Aims Mechanical forces contribute to portal hypertension (PHTN) and
fibrogenesis. We investigated the mechanisms by which forces are transduced by liver …

Human amniotic mesenchymal stem cells-derived IGFBP-3, DKK-3, and DKK-1 attenuate liver fibrosis through inhibiting hepatic stellate cell activation by blocking Wnt …

QW Liu, YM Ying, JX Zhou, WJ Zhang, Z Liu… - Stem cell research & …, 2022 - Springer
Background Liver fibrosis is an outcome of restoring process in chronic liver injury. Human
amniotic mesenchymal stem cells (hAMSCs) derived from amniotic membrane have …

Fontan-associated liver disease: proceedings from the American College of Cardiology Stakeholders Meeting, October 1 to 2, 2015, Washington DC

CJ Daniels, EA Bradley, MJ Landzberg… - Journal of the American …, 2017 - jacc.org
Over the past decade, as the majority of patients with single ventricle anatomy who have
undergone the Fontan operation reach adulthood, a newly recognized disease process …

Exosome adherence and internalization by hepatic stellate cells triggers sphingosine 1-phosphate-dependent migration

R Wang, Q Ding, U Yaqoob, TM de Assuncao… - Journal of biological …, 2015 - ASBMB
Exosomes are cell-derived extracellular vesicles thought to promote intercellular
communication by delivering specific content to target cells. The aim of this study was to …

The portal hypertension syndrome: etiology, classification, relevance, and animal models

J Bosch, Y Iwakiri - Hepatology international, 2018 - Springer
Background Portal hypertension is a key complication of portal hypertension, which is
responsible for the development of varices, ascites, bleeding, and hepatic encephalopathy …

Ultrasound elastography and MR elastography for assessing liver fibrosis: part 2, diagnostic performance, confounders, and future directions

A Tang, G Cloutier, NM Szeverenyi… - American journal of …, 2015 - Am Roentgen Ray Soc
OBJECTIVE. The purpose of the article is to review the diagnostic performance of ultra-
sound and MR elastography techniques for detection and staging of liver fibrosis, the main …