A facile approach synthesis of benzoylaryl benzimidazole as potential α-amylase and α-glucosidase inhibitor with antioxidant activity
LM Aroua, HR Almuhaylan, FM Alminderej… - Bioorganic …, 2021 - Elsevier
Synthetic routes to a series of benzoylarylbenzimidazol 3a-h have been derived from 3, 4-
diaminobenzophenone and an appropriate arylaldehyde in the presence of ammonium …
diaminobenzophenone and an appropriate arylaldehyde in the presence of ammonium …
Recent developments in the synthesis of N‐heterocyclic compounds as α‐amylase inhibitors via in‐vitro and in‐silico analysis: Future drugs for treating diabetes
In nature, N‐heterocyclic compounds and their derivatives are abundant. They serve as the
building blocks of many biological entities, such as enzymes, alkaloids, hormones …
building blocks of many biological entities, such as enzymes, alkaloids, hormones …
In vitro antimicrobial and α-glucosidase inhibitory potential of enantiopure cycloalkylglycine derivatives: Insights into their in silico pharmacokinetic, druglikeness, and …
A Kadri, K Aouadi - Journal of Applied Pharmaceutical Science, 2020 - japsonline.com
The present investigation deals with the evaluation for the first time of the in vitro
antimicrobial and α-glucosidase inhibitory potential of a series of 15 enantiopure …
antimicrobial and α-glucosidase inhibitory potential of a series of 15 enantiopure …
Novel fused pyridine derivatives containing pyrimidine moiety as prospective tyrosyl-tRNA synthetase inhibitors: Design, synthesis, pharmacokinetics and molecular …
IMM Othman, MAM Gad-Elkareem, M Snoussi… - Journal of Molecular …, 2020 - Elsevier
Thirteen fused pyridine derivatives have been designed, synthesized and characterized by 1
H NMR, 13 C NMR and IR spectral data and elemental analysis. Their in vitro antimicrobial …
H NMR, 13 C NMR and IR spectral data and elemental analysis. Their in vitro antimicrobial …
Design, synthesis ADMET and molecular docking of new imidazo [4, 5-b] pyridine-5-thione derivatives as potential tyrosyl-tRNA synthetase inhibitors
IMM Othman, MAM Gad-Elkareem, K Aouadi… - Bioorganic …, 2020 - Elsevier
In our effort of discovering new antimicrobial agents, a novel series of imidazo [4, 5-b]
pyridine-5-thione scaffolds were designed and synthesized and their chemical structures …
pyridine-5-thione scaffolds were designed and synthesized and their chemical structures …
Multifunctional derivatives of Spiropyrrolidine tethered Indeno-Quinoxaline heterocyclic hybrids as potent antimicrobial, antioxidant and antidiabetic agents: design …
To combat emerging antimicrobial-resistant microbes, there is an urgent need to develop
new antimicrobials with better therapeutic profiles. For this, a series of 13 new …
new antimicrobials with better therapeutic profiles. For this, a series of 13 new …
Design and synthesis of novel enantiopure Bis (5-Isoxazolidine) derivatives: insights into their antioxidant and antimicrobial potential via in silico drug-likeness …
ALA Arwa, M ALSaeedy, A Alrabie, I Al-Qadsy… - Heliyon, 2022 - cell.com
A series of novel compounds, mono-5-isoxazolidines, and bis (5-isoxazolidines) derivatives,
were prepared as bicycloadducts. The new series of isoxazolidines were designed and …
were prepared as bicycloadducts. The new series of isoxazolidines were designed and …
Investigation of novel benzimidazole-based indole/thiazole hybrids derivatives as effective anti-diabetics and anti-alzheimer's agents: Structure-activity relationship …
Alzheimer's disease (AD) and type 2 diabetes mellitus (T2DM) are common in developed
countries and their incidence is increasing. The research is mostly concentrated on the …
countries and their incidence is increasing. The research is mostly concentrated on the …
Novel enantiopure isoxazolidine and C-alkyl imine oxide derivatives as potential hypoglycemic agents: Design, synthesis, dual inhibitors of α-amylase and α …
In an effort to explore a new class of antidiabetic inhibitors, a new series of isoxazolidine and
C-alkyl imine oxide derivatives scaffolds were designed, synthesized and fully …
C-alkyl imine oxide derivatives scaffolds were designed, synthesized and fully …
A reversible optical sensor film for mercury ions discrimination based on isoxazolidine derivative and exhibiting pH sensing
We developed a new optical sensor for tracing Hg (II) ions. The detection affinity examines
within a concentration range of 0–4.0 µM Hg (II). The sensor film is based on Methyl 2 …
within a concentration range of 0–4.0 µM Hg (II). The sensor film is based on Methyl 2 …