Molecular mechanisms of poxvirus evolution
Poxviruses are often thought to evolve relatively slowly because they are double-stranded
DNA pathogens with proofreading polymerases. However, poxviruses have highly …
DNA pathogens with proofreading polymerases. However, poxviruses have highly …
African swine fever modified live vaccine candidates: Transitioning from discovery to product development through harmonized standards and guidelines
DA Brake - Viruses, 2022 - mdpi.com
The recent centennial anniversary of RE Montgomery's seminal published description of “a
form of swine fever” disease transmitted from wild African pigs to European domestic pigs is …
form of swine fever” disease transmitted from wild African pigs to European domestic pigs is …
Poxvirus recombination
DH Evans - Pathogens, 2022 - mdpi.com
Genetic recombination is used as a tool for modifying the composition of poxvirus genomes
in both discovery and applied research. This review documents the history behind the …
in both discovery and applied research. This review documents the history behind the …
Extensive ITR expansion of the 2022 Mpox virus genome through gene duplication and gene loss
A Brinkmann, C Kohl, K Pape, D Bourquain, A Thürmer… - Virus Genes, 2023 - Springer
Poxviruses are known to evolve slower than RNA viruses with only 1–2 mutations/genome/
year. Rather than single mutations, rearrangements such as gene gain and loss, which have …
year. Rather than single mutations, rearrangements such as gene gain and loss, which have …
[HTML][HTML] Capripoxviruses, leporipoxviruses, and orthopoxviruses: Occurrences of recombination
A Sprygin, A Mazloum, A Van Schalkwyk… - Frontiers in …, 2022 - frontiersin.org
Poxviruses are double-stranded DNA viruses with several members displaying restricted
host ranges. They are genetically stable with low nucleotide mutation rates compared to …
host ranges. They are genetically stable with low nucleotide mutation rates compared to …
Whole genome sequencing of recombinant viruses obtained from co-infection and superinfection of Vero cells with modified vaccinia virus ankara vectored influenza …
D Diaz-Cánova, U Moens, A Brinkmann… - Frontiers in …, 2024 - frontiersin.org
Modified vaccinia virus Ankara (MVA) has been widely tested in clinical trials as
recombinant vector vaccine against infectious diseases and cancers in humans and …
recombinant vector vaccine against infectious diseases and cancers in humans and …
Possible adaption of the 2022 Monkeypox virus to the human host through gene duplication and loss
A Brinkmann, C Kohl, K Pape, D Bourquain, A Thürmer… - bioRxiv, 2022 - biorxiv.org
Poxviruses are known to evolve slower than RNA viruses, with rearrangements such as
gene gain and loss as the main driver for host adaption. In 2022 the world is being …
gene gain and loss as the main driver for host adaption. In 2022 the world is being …
Viral nucleases from herpesviruses and coronavirus in recombination and proofreading: potential targets for antiviral drug discovery
LR Wright, DL Wright, SK Weller - Viruses, 2022 - mdpi.com
In this review, we explore recombination in two very different virus families that have become
major threats to human health. The Herpesviridae are a large family of pathogenic double …
major threats to human health. The Herpesviridae are a large family of pathogenic double …
Differences in pathogenicity among the mpox virus clades: impact on drug discovery and vaccine development
G Andrei, R Snoeck - Trends in Pharmacological Sciences, 2023 - cell.com
Since May 2022, mpox virus (MPXV) has attracted considerable attention due to a multi-
country outbreak. Marked differences in epidemiology, transmission, and pathology between …
country outbreak. Marked differences in epidemiology, transmission, and pathology between …