Macrophages: the good, the bad, and the gluttony

EA Ross, A Devitt, JR Johnson - Frontiers in immunology, 2021 - frontiersin.org
Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …

The pathogenesis of psoriatic arthritis

DJ Veale, U Fearon - The Lancet, 2018 - thelancet.com
Psoriatic arthritis is a chronic, immune-mediated, inflammatory arthropathy that presents with
inflammation of the joints and entheses, including those of the axial skeleton, and is …

Macrophage M1/M2 polarization and rheumatoid arthritis: a systematic review

S Tardito, G Martinelli, S Soldano, S Paolino… - Autoimmunity …, 2019 - Elsevier
Background and aim Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory
disease; the clinical manifestations are correlated with continuum multiarticular synovitis …

Macrophage plasticity and polarization: in vivo veritas

A Sica, A Mantovani - The Journal of clinical investigation, 2012 - Am Soc Clin Investig
Diversity and plasticity are hallmarks of cells of the monocyte-macrophage lineage. In
response to IFNs, Toll-like receptor engagement, or IL-4/IL-13 signaling, macrophages …

Immune modulation of some autoimmune diseases: the critical role of macrophages and neutrophils in the innate and adaptive immunity

KC Navegantes, R de Souza Gomes… - Journal of translational …, 2017 - Springer
Macrophages and neutrophils are key components involved in the regulation of numerous
chronic inflammatory diseases, infectious disorders, and especially certain autoimmune …

Spondyloarthritis

M Dougados, D Baeten - The Lancet, 2011 - thelancet.com
Spondyloarthritis is a group of several related but phenotypically distinct disorders: psoriatic
arthritis, arthritis related to inflammatory bowel disease, reactive arthritis, a subgroup of …

Emerging role of targeting macrophages in rheumatoid arthritis: focus on polarization, metabolism and apoptosis

X Yang, Y Chang, W Wei - Cell proliferation, 2020 - Wiley Online Library
Macrophages maintain a dynamic balance in physiology. Various known or unknown
microenvironmental signals influence the polarization, activation and death of macrophages …

Systematic validation of specific phenotypic markers for in vitro polarized human macrophages

CA Ambarus, S Krausz, M van Eijk, J Hamann… - Journal of …, 2012 - Elsevier
BACKGROUND: Polarization of macrophages by specific micro-environmental conditions
impacts upon their function following subsequent activation. This study aimed to …

Analysis of IL-17+cells in facet joints of patients with spondyloarthritis suggests that the innate immune pathway might be of greater relevance than the Th17-mediated …

H Appel, R Maier, P Wu, R Scheer, A Hempfing… - Arthritis research & …, 2011 - Springer
Introduction In this study, we analysed the number of IL-17+ cells in facet joints, in the
peripheral blood (PB) and synovial fluid (SF) of spondyloarthritis (SpA) patients and …

Macrophages with regulatory functions, a possible new therapeutic perspective in autoimmune diseases

P Di Benedetto, P Ruscitti, Z Vadasz, E Toubi… - Autoimmunity …, 2019 - Elsevier
Macrophages are pivotal cells involved in chronic inflammatory and autoimmune diseases.
In fact, during these diseases, activated macrophages may play a critical role, promoting the …