Molecular Machines that Facilitate Bacterial Outer Membrane Protein Biogenesis
MT Doyle, HD Bernstein - Annual Review of Biochemistry, 2024 - annualreviews.org
Almost all outer membrane proteins (OMPs) in Gram-negative bacteria contain a β-barrel
domain that spans the outer membrane (OM). To reach the OM, OMPs must be translocated …
domain that spans the outer membrane (OM). To reach the OM, OMPs must be translocated …
A novel decoy strategy for polymyxin resistance in Acinetobacter baumannii
Modification of the outer membrane charge by a polymyxin B (PMB)-induced PmrAB two-
component system appears to be a dominant phenomenon in PMB-resistant Acinetobacter …
component system appears to be a dominant phenomenon in PMB-resistant Acinetobacter …
ATP‐independent assembly machinery of bacterial outer membranes: BAM complex structure and function set the stage for next‐generation therapeutics
A George, AG Patil, R Mahalakshmi - Protein Science, 2024 - Wiley Online Library
Diderm bacteria employ β‐barrel outer membrane proteins (OMPs) as their first line of
communication with their environment. These OMPs are assembled efficiently in the …
communication with their environment. These OMPs are assembled efficiently in the …
[PDF][PDF] A mobile CRISPRi collection enables genetic interaction studies for the essential genes of Escherichia coli
Advances in gene editing, in particular CRISPR interference (CRISPRi), have enabled
depletion of essential cellular machinery to study the downstream effects on bacterial …
depletion of essential cellular machinery to study the downstream effects on bacterial …
[HTML][HTML] LptM promotes oxidative maturation of the lipopolysaccharide translocon by substrate binding mimicry
Insertion of lipopolysaccharide (LPS) into the bacterial outer membrane (OM) is mediated by
a druggable OM translocon consisting of a β-barrel membrane protein, LptD, and a …
a druggable OM translocon consisting of a β-barrel membrane protein, LptD, and a …
[HTML][HTML] Overexpression of the Bam Complex Improves the Production of Chlamydia trachomatis MOMP in the E. coli Outer Membrane
DT Huynh, WSP Jong, GM Koningstein… - International Journal of …, 2022 - mdpi.com
A licensed Chlamydia trachomatis (Ct) vaccine is not yet available. Recombinant Chlamydia
trachomatis major outer membrane protein (Ct-MOMP), the most abundant constituent of the …
trachomatis major outer membrane protein (Ct-MOMP), the most abundant constituent of the …
A bacterial secretosome for regulated envelope biogenesis and quality control?
DW Watkins, SL Williams, I Collinson - Microbiology, 2022 - microbiologyresearch.org
The Gram-negative bacterial envelope is the first line of defence against environmental
stress and antibiotics. Therefore, its biogenesis is of considerable fundamental interest, as …
stress and antibiotics. Therefore, its biogenesis is of considerable fundamental interest, as …
Bam complex associated proteins in Escherichia coli are functionally linked to peptidoglycan biosynthesis, membrane fluidity and DNA replication
Biogenesis of the bacterial outer membrane is key to bacterial survival and antibiotic
resistance. Central to this is the β-barrel assembly machine (Bam) complex and its …
resistance. Central to this is the β-barrel assembly machine (Bam) complex and its …
The lipoprotein DolP affects cell separation in Escherichia coli, but not as an upstream regulator of NlpD
Bacterial amidases are essential to split the shared envelope of adjunct daughter cells to
allow cell separation. Their activity needs to be precisely controlled to prevent cell lysis. In …
allow cell separation. Their activity needs to be precisely controlled to prevent cell lysis. In …
BonA from Acinetobacter baumannii Forms a Divisome-Localized Decamer That Supports Outer Envelope Function
Acinetobacter baumannii is a high-risk pathogen due to the rapid global spread of multidrug-
resistant lineages. Its phylogenetic divergence from other ESKAPE pathogens means that …
resistant lineages. Its phylogenetic divergence from other ESKAPE pathogens means that …