Brain-derived neurotrophic factor in mood disorders and antidepressant treatments
Levels of brain-derived neurotrophic factor (BDNF) are reduced in the brain and serum of
depressed patients and at least the reduction in serum levels is reversible upon successful …
depressed patients and at least the reduction in serum levels is reversible upon successful …
Annual research review: The neurobiology and physiology of resilience and adaptation across the life course
IN Karatsoreos, BS McEwen - Journal of Child Psychology and …, 2013 - Wiley Online Library
Background Adaptation is key to survival. An organism must adapt to environmental
challenges in order to be able to thrive in the environment in which they find themselves …
challenges in order to be able to thrive in the environment in which they find themselves …
Subretinally injected semiconducting polymer nanoparticles rescue vision in a rat model of retinal dystrophy
JF Maya-Vetencourt, G Manfredi, M Mete… - Nature …, 2020 - nature.com
Inherited retinal dystrophies and late-stage age-related macular degeneration, for which
treatments remain limited, are among the most prevalent causes of legal blindness. Retinal …
treatments remain limited, are among the most prevalent causes of legal blindness. Retinal …
Wiring and molecular features of prefrontal ensembles representing distinct experiences
A major challenge in understanding the cellular diversity of the brain has been linking
activity during behavior with standard cellular typology. For example, it has not been …
activity during behavior with standard cellular typology. For example, it has not been …
Npas4 regulates excitatory-inhibitory balance within neural circuits through cell-type-specific gene programs
The nervous system adapts to experience by inducing a transcriptional program that controls
important aspects of synaptic plasticity. Although the molecular mechanisms of experience …
important aspects of synaptic plasticity. Although the molecular mechanisms of experience …
A fully organic retinal prosthesis restores vision in a rat model of degenerative blindness
The degeneration of photoreceptors in the retina is one of the major causes of adult
blindness in humans. Unfortunately, no effective clinical treatments exist for the majority of …
blindness in humans. Unfortunately, no effective clinical treatments exist for the majority of …
Npas4: linking neuronal activity to memory
X Sun, Y Lin - Trends in neurosciences, 2016 - cell.com
Immediate-early genes (IEGs) are rapidly activated after sensory and behavioral experience
and are believed to be crucial for converting experience into long-term memory. Neuronal …
and are believed to be crucial for converting experience into long-term memory. Neuronal …
NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses
Chronic stress can produce reward system deficits (ie, anhedonia) and other common
symptoms associated with depressive disorders, as well as neural circuit hypofunction in the …
symptoms associated with depressive disorders, as well as neural circuit hypofunction in the …
Synapse development organized by neuronal activity-regulated immediate-early genes
Classical studies have shown that neuronal immediate-early genes (IEGs) play important
roles in synaptic processes critical for key brain functions. IEGs are transiently activated and …
roles in synaptic processes critical for key brain functions. IEGs are transiently activated and …
Fluoxetine maintains a state of heightened responsiveness to motor training early after stroke in a mouse model
KL Ng, EM Gibson, R Hubbard, J Yang, B Caffo… - Stroke, 2015 - Am Heart Assoc
Background and Purpose—Data from both humans and animal models suggest that most
recovery from motor impairment after stroke occurs in a sensitive period that lasts only …
recovery from motor impairment after stroke occurs in a sensitive period that lasts only …