Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Covering: up to the end of 2022 Microorganisms are exceptional sources of a wide array of
unique natural products and play a significant role in drug discovery. During the golden era …

Dietary fibres can exert beneficial anti-inflammatory effects through microbially fermented
short-chain fatty acid metabolites,, although the immunoregulatory roles of most fibre diets …

Consumption of dietary lipids, such as cholesterol, modulates the gut microbiome with
consequences for host health through the production of microbiome-derived metabolites …

Advances in bioanalytical technologies are constantly expanding our insights into complex
ecosystems. Here, we highlight strategies and applications that make use of non-targeted …

Microbially-derived gut metabolites are important contributors to host phenotypes, many of
which may link microbiome composition to metabolic disease. However, relatively few …

Recent studies of animal metabolism have revealed large numbers of novel metabolites that
are involved in all aspects of organismal biology, but it is unclear to what extent …

The neurotransmitter serotonin plays a central role in animal behavior and physiology, and
many of its functions are regulated via evolutionarily conserved biosynthesis and …

Bile acids regulate nutrient absorption and mitochondrial function, they establish and
maintain gut microbial community composition and mediate inflammation, and they serve as …

Multiclass metabolomics has been widely applied in clinical practice to understand
pathophysiological processes involved in disease progression and diagnostic biomarkers of …