Application of mesenchymal stem cells in inflammatory and fibrotic diseases

JS Ryu, EJ Jeong, JY Kim, SJ Park, WS Ju… - International Journal of …, 2020 - mdpi.com
Mesenchymal stem cells (MSCs) are multipotent stem cells that can be isolated from various
tissues in the adult body. MSCs should be characterized by three criteria for regenerative …

Nasal polyposis: insights in epithelial-mesenchymal transition and differentiation of polyp mesenchymal stem cells

E Chiarella, N Lombardo, N Lobello, A Aloisio… - International journal of …, 2020 - mdpi.com
Chronic rhinosinusitis is a common inflammatory disease of paranasal sinuses, which
causes rhinorrhea, nasal congestion, and hyposmia. The genetic predisposition or the …

Cellular and Biochemical Characterization of Mesenchymal Stem Cells from Killian Nasal Polyp

M Mesuraca, C Nisticò, N Lombardo… - International Journal of …, 2022 - mdpi.com
Killian's (antrochoanal) polyp is a unilateral nasal polypoid lesion of the maxillary sinus
especially affecting children and young adults with unilateral nasal obstruction, pus …

Comparison of biological characteristics of mesenchymal stem cells derived from maternal-origin placenta and Wharton's jelly

G Chen, A Yue, Z Ruan, Y Yin, R Wang, Y Ren… - Stem cell research & …, 2015 - Springer
Introduction Although mesenchymal stem cells (MSCs) from different sources share many
similar characteristics, they also exhibit individual properties. In this study, we compared …

Managing chronic rhinosinusitis with nasal polyps in the elderly: challenges and solutions

T Merrill, A Kanaan - Clinical Interventions in Aging, 2023 - Taylor & Francis
The proportion of the population over 65 years old continues to grow. Chronic rhinosinusitis
is common in this population and causes a reduction in quality of life and an increase in …

A phase IB/IIA study of remestemcel‐L, an allogeneic bone marrow‐derived mesenchymal stem cell product, for the treatment of medically refractory ulcerative colitis …

AL Lightner, N Dadgar, C Matyas, K Elliott… - Colorectal …, 2022 - Wiley Online Library
Aim There have been no studies into the direct injection of mesenchymal stem cells (MSCs)
for luminal ulcerative colitis (UC). Our aim was to investigate the efficacy of MSCs delivered …

Durable Response in Patients With Refractory Fistulizing Perianal Crohn's Disease Using Autologous Mesenchymal Stem Cells on a Dissolvable Matrix: Results from …

EJ Dozois, AL Lightner, AB Dietz… - Diseases of the Colon …, 2023 - journals.lww.com
BACKGROUND: Refractory perianal Crohn's disease remains notoriously difficult to treat.
We developed a novel technology using a commercially available bioabsorbable fistula plug …

BMP-7, MMP-9, and TGF-β tissue remodeling proteins and their correlations with interleukins 6 and 10 in chronic rhinosinusitis

BR Lucas, RL Voegels, JB do Amaral… - European Archives of …, 2021 - Springer
Introduction Chronic rhinosinusitis without nasal polyposis (CRSsNP) and Chronic
rhinosinusitis with nasal polyposis (CRSwNP) present distinct tissue remodeling processes …

Effect of comedications and endotoxins on mesenchymal stem cell secretomes, migratory and immunomodulatory capacity

N Durand, A Russell, AC Zubair - Journal of Clinical Medicine, 2019 - mdpi.com
Mesenchymal stem cells (MSCs) are becoming an increasingly popular therapeutic option
among patients with a broad range of ailments to modulate immunity and induce …

Nasal polyp-derived mesenchymal stromal cells exhibit lack of immune-associated molecules and high levels of stem/progenitor cells markers

PWB Oliveira, R Pezato, JSH Agudelo… - Frontiers in …, 2017 - frontiersin.org
Mesenchymal stromal cells (MSCs) are considered adult progenitor stem cells and have
been studied in a multitude of tissues. In this context, the microenvironment of nasal polyp …