Where are the disease-associated eQTLs?
Most disease-associated variants, although located in putatively regulatory regions, do not
have detectable effects on gene expression. One explanation could be that we have not …
have detectable effects on gene expression. One explanation could be that we have not …
Current advances in primate genomics: novel approaches for understanding evolution and disease
Primate genomics holds the key to understanding fundamental aspects of human evolution
and disease. However, genetic diversity and functional genomics data sets are currently …
and disease. However, genetic diversity and functional genomics data sets are currently …
Hepatoprotective Effect of Mitochondria‐Targeted Antioxidant Mito‐TEMPO against Lipopolysaccharide‐Induced Liver Injury in Mouse
PF Wang, K Xie, YX Cao, A Zhang - Mediators of inflammation, 2022 - Wiley Online Library
The liver is vulnerable to sepsis, and sepsis‐induced liver injury is closely associated with
poor survival of sepsis patients. Studies have found that the overproduction of reactive …
poor survival of sepsis patients. Studies have found that the overproduction of reactive …
Ancient hybridization and strong adaptation to viruses across African vervet monkey populations
Vervet monkeys are among the most widely distributed nonhuman primates, show
considerable phenotypic diversity, and have long been an important biomedical model for a …
considerable phenotypic diversity, and have long been an important biomedical model for a …
Gene expression variability in human and chimpanzee populations share common determinants
Inter-individual variation in gene expression has been shown to be heritable and is often
associated with differences in disease susceptibility between individuals. Many studies …
associated with differences in disease susceptibility between individuals. Many studies …
A generally conserved response to hypoxia in iPSC-derived cardiomyocytes from humans and chimpanzees
Despite anatomical similarities, there are differences in susceptibility to cardiovascular
disease (CVD) between primates; humans are prone to myocardial ischemia, while …
disease (CVD) between primates; humans are prone to myocardial ischemia, while …
Epigenetic clock and methylation studies in vervet monkeys
DNA methylation-based biomarkers of aging have been developed for many mammals but
not yet for the vervet monkey (Chlorocebus sabaeus), which is a valuable non-human …
not yet for the vervet monkey (Chlorocebus sabaeus), which is a valuable non-human …
The evolution of the human DNA replication timing program
AN Bracci, A Dallmann, Q Ding… - Proceedings of the …, 2023 - National Acad Sciences
DNA is replicated according to a defined spatiotemporal program that is linked to both gene
regulation and genome stability. The evolutionary forces that have shaped replication timing …
regulation and genome stability. The evolutionary forces that have shaped replication timing …
Morphological variation in the genus Chlorocebus: Ecogeographic and anthropogenically mediated variation in body mass, postcranial morphology, and growth
Objectives Direct comparative work in morphology and growth on widely dispersed wild
primate taxa is rarely accomplished, yet critical to understanding ecogeographic variation …
primate taxa is rarely accomplished, yet critical to understanding ecogeographic variation …
A causal association of ANKRD37 with human hippocampal volume
Human hippocampal volume has been separately associated with single nucleotide
polymorphisms (SNPs), DNA methylation and gene expression, but their causal …
polymorphisms (SNPs), DNA methylation and gene expression, but their causal …