Synaptic functions of endocannabinoid signaling in health and disease
Endocannabinoids (eCBs) are a family of lipid molecules that act as key regulators of
synaptic transmission and plasticity. They are synthetized “on demand” following …
synaptic transmission and plasticity. They are synthetized “on demand” following …
Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms
Amphetamine-related drugs, such as 3, 4-methylenedioxymethamphetamine (MDMA) and
methamphetamine (METH), are popular recreational psychostimulants. Several preclinical …
methamphetamine (METH), are popular recreational psychostimulants. Several preclinical …
Endocannabinoid modulation of dopamine neurotransmission
Dopamine (DA) is a major catecholamine neurotransmitter in the mammalian brain that
controls neural circuits involved in the cognitive, emotional, and motor aspects of goal …
controls neural circuits involved in the cognitive, emotional, and motor aspects of goal …
The modulatory role of dopamine in anxiety-like behavior
MR ZARRINDAST, F Khakpai - 2015 - sid.ir
ANXIETY is an unpleasant physiological state in which an overreaction to a situation occurs.
It has been suggested that different brain regions are involved in the modulation and …
It has been suggested that different brain regions are involved in the modulation and …
[HTML][HTML] Cannabinoid receptors CB1 and CB2 form functional heteromers in brain
L Callén, E Moreno, P Barroso-Chinea… - Journal of Biological …, 2012 - ASBMB
Exploring the role of cannabinoid CB 2 receptors in the brain, we present evidence of CB 2
receptor molecular and functional interaction with cannabinoid CB 1 receptors. Using …
receptor molecular and functional interaction with cannabinoid CB 1 receptors. Using …
Microglia activation states and cannabinoid system: Therapeutic implications
Microglial cells are recognized as the brain's intrinsic immune cells, mediating actions that
range from the protection against harmful conditions that modify CNS homeostasis, to the …
range from the protection against harmful conditions that modify CNS homeostasis, to the …
Deficits in striatal dopamine release in cannabis dependence
Most drugs of abuse lead to a general blunting of dopamine release in the chronic phase of
dependence, which contributes to poor outcome. To test whether cannabis dependence is …
dependence, which contributes to poor outcome. To test whether cannabis dependence is …
Crosstalk between the transcriptional regulation of dopamine D2 and cannabinoid CB1 receptors in schizophrenia: Analyses in patients and in perinatal Δ9 …
Perinatal exposure to Δ 9-tetrahydrocannabinol (THC) affects brain development and might
increase the incidence of psychopathology later in life, which seems to be related to a …
increase the incidence of psychopathology later in life, which seems to be related to a …
[HTML][HTML] Promising cannabinoid-based therapies for Parkinson's disease: motor symptoms to neuroprotection
Parkinson's disease (PD) is a slow insidious neurological disorder characterized by a loss of
dopaminergic neurons in the midbrain. Although several recent preclinical advances have …
dopaminergic neurons in the midbrain. Although several recent preclinical advances have …
[HTML][HTML] Targeting anandamide metabolism rescues core and associated autistic-like symptoms in rats prenatally exposed to valproic acid
M Servadio, F Melancia, A Manduca, A Di Masi… - Translational …, 2016 - nature.com
Autism spectrum disorders (ASD) are characterized by altered sociability, compromised
communication and stereotyped/repetitive behaviors, for which no specific treatments are …
communication and stereotyped/repetitive behaviors, for which no specific treatments are …