In 1925, 5-methylcytosine was first reported in bacteria. However, its biological importance
was not intuitive for several decades. After this initial lag, the ubiquitous presence of this …

DNA methylation is a major epigenetic process that regulates chromatin structure which
causes transcriptional activation or repression of genes in a context-dependent manner. In …

Biomolecular condensates are dense assemblies of proteins that form distinct biochemical
compartments without being surrounded by a membrane. Some, such as P granules and …

Circulating tumor DNA (ctDNA) has emerged as a useful diagnostic and prognostic
biomarker in many cancers. Here, we conducted a study to investigate the potential use of …

Expression of a few master transcription factors can reprogram the epigenetic landscape
and three-dimensional chromatin topology of differentiated cells and achieve pluripotency …

Epigenetic DNA modification impacts gene expression, but the underlying molecular
mechanisms are only partly understood. Adding a methyl group to a cytosine base locally …

MicroRNAs (miRNAs) are widely present in many organisms and regulate the expression of
genes in various biological processes such as cell differentiation, metabolism, and …

DNA methylation is an essential part of the epigenome chromatin modification network,
which also comprises several covalent histone protein post-translational modifications. All …

DNA methylation is a prevalent epigenetic modification involved in regulating a number of
essential cellular processes, including genomic accessibility and transcriptional outcomes …

Background Breast cancer (BC) is the most frequently diagnosed cancer and a leading
cause of death among women worldwide. Early BC is potentially curable, but the mortality …