Multimorbidity (two or more coexisting conditions in an individual) is a growing global
challenge with substantial effects on individuals, carers and society. Multimorbidity occurs a …

Cancer is a disease of aging and, as the world's population ages, the number of older
persons with cancer is increasing and will make up a growing share of the oncology …

Summary Background Randomised controlled trials (RCTs) inform prescription guidelines,
but stringent eligibility criteria exclude individuals with vulnerable characteristics, which we …

There is a growing focus on making clinical trials more inclusive but the design of trial
eligibility criteria remains challenging,–. Here we systematically evaluate the effect of …

The Consolidated Standards of Reporting Trials (CONSORT) statement is a guideline
designed to improve the transparency and quality of the reporting of randomised controlled …

Randomized controlled trials (RCTs) are conducted under idealized and rigorously
controlled conditions that may compromise their external validity. A literature review was …

Hypertension is a highly prevalent condition with numerous health risks, and the incidence
of hypertension is greatest among older adults. Traditional discussions of hypertension have …

Objectives To compare re-rupture rate, complication rate, and functional outcome after
operative versus nonoperative treatment of Achilles tendon ruptures; to compare re-rupture …

Background The escalating use of prescribed drugs has increasingly raised concerns about
polypharmacy. This study aims to examine changes in rates of polypharmacy and potentially …

The concept of multimorbidity has attracted growing interest over recent years, and more
latterly with the publication of specific guidelines on multimorbidity by the National Institute …