Glaucoma is the leading cause of irreversible blindness globally. The disease causes vision
loss due to neurodegeneration of the retinal ganglion cell (RGC) projection to the brain …

The retina is the sensory tissue responsible for the first stages of visual processing, with a
conserved anatomy and functional architecture among vertebrates. To date, retinal eye …

Dendrite pathology and synaptic loss result in neural circuit dysfunction, a common feature
of neurodegenerative diseases. There is a lack of strategies that target dendritic and …

The vasculature of the central nervous system is a 3D lattice composed of laminar vascular
beds interconnected by penetrating vessels. The mechanisms controlling 3D lattice network …

In an attempt to repair injured central nervous system (CNS) nerves/tracts, immune cells are
recruited into the injury site, but endogenous response in adult mammals is insufficient for …

While preclinical efforts continue in several laboratories, an increasing number of start-up
and large pharmaceutical companies are working on developing gene therapeutics for …

Hereditary optic neuropathies (HONs) such as dominant optic atrophy (DOA) and Leber
Hereditary Optic Neuropathy (LHON) are mitochondrial diseases characterized by a …

The Myc family of proto-oncogenes is a key node for the signal transduction of external pro-
proliferative signals to the cellular processes required for development, tissue homoeostasis …

Introduction: Advances in machine vision and mobile electronics will be accelerated by the
creation of sophisticated optoelectronic vision sensors that allow for sophisticated picture …

Purpose: Retinal ganglion cell (RGC) loss provides the basis for diagnosis and stage
determination of many optic neuropathies, and quantification of RGC survival is a critical …