Synthetic biology in the clinic: engineering vaccines, diagnostics, and therapeutics
Synthetic biology is a design-driven discipline centered on engineering novel biological
functions through the discovery, characterization, and repurposing of molecular parts …
functions through the discovery, characterization, and repurposing of molecular parts …
Inhibitors of bacterial immune systems: discovery, mechanisms and applications
D Mayo-Muñoz, R Pinilla-Redondo… - Nature Reviews …, 2024 - nature.com
To contend with the diversity and ubiquity of bacteriophages and other mobile genetic
elements, bacteria have developed an arsenal of immune defence mechanisms. Bacterial …
elements, bacteria have developed an arsenal of immune defence mechanisms. Bacterial …
AcrPred: A hybrid optimization with enumerated machine learning algorithm to predict Anti-CRISPR proteins
CRISPR-Cas, as a tool for gene editing, has received extensive attention in recent years.
Anti-CRISPR (Acr) proteins can inactivate the CRISPR-Cas defense system during …
Anti-CRISPR (Acr) proteins can inactivate the CRISPR-Cas defense system during …
PhageScope: a well-annotated bacteriophage database with automatic analyses and visualizations
Bacteriophages are viruses that infect bacteria or archaea. Understanding the diverse and
intricate genomic architectures of phages is essential to study microbial ecosystems and …
intricate genomic architectures of phages is essential to study microbial ecosystems and …
A versatile active learning workflow for optimization of genetic and metabolic networks
Optimization of biological networks is often limited by wet lab labor and cost, and the lack of
convenient computational tools. Here, we describe METIS, a versatile active machine …
convenient computational tools. Here, we describe METIS, a versatile active machine …
Engineered bacteriophage therapeutics: rationale, challenges and future
M Łobocka, K Dąbrowska, A Górski - BioDrugs, 2021 - Springer
The current problems with increasing bacterial resistance to antibacterial therapies, resulting
in a growing frequency of incurable bacterial infections, necessitates the acceleration of …
in a growing frequency of incurable bacterial infections, necessitates the acceleration of …
Incorporating machine learning into established bioinformatics frameworks
N Auslander, AB Gussow, EV Koonin - International journal of molecular …, 2021 - mdpi.com
The exponential growth of biomedical data in recent years has urged the application of
numerous machine learning techniques to address emerging problems in biology and …
numerous machine learning techniques to address emerging problems in biology and …
CRISPRimmunity: an interactive web server for CRISPR-associated Important Molecular events and Modulators Used in geNome edIting Tool identifYing
F Zhou, X Yu, R Gan, K Ren, C Chen… - Nucleic acids …, 2023 - academic.oup.com
The CRISPR-Cas system is a highly adaptive and RNA-guided immune system found in
bacteria and archaea, which has applications as a genome editing tool and is a valuable …
bacteria and archaea, which has applications as a genome editing tool and is a valuable …
Recent advances in improving gene-editing specificity through CRISPR–Cas9 nuclease engineering
CRISPR–Cas9 is the state-of-the-art programmable genome-editing tool widely used in
many areas. For safe therapeutic applications in clinical medicine, its off-target effect must …
many areas. For safe therapeutic applications in clinical medicine, its off-target effect must …
Prophage integration into CRISPR loci enables evasion of antiviral immunity in Streptococcus pyogenes
CRISPR loci are composed of short DNA repeats separated by sequences, known as
spacers, that match the genomes of invaders such as phages and plasmids. Spacers are …
spacers, that match the genomes of invaders such as phages and plasmids. Spacers are …