Therapeutic antisense oligonucleotides against cancer: hurdling to the clinic
PMD Moreno, AP Pêgo - Frontiers in chemistry, 2014 - frontiersin.org
Under clinical development since the early 90's and with two successfully approved drugs
(Fomivirsen and Mipomersen), oligonucleotide-based therapeutics has not yet delivered a …
(Fomivirsen and Mipomersen), oligonucleotide-based therapeutics has not yet delivered a …
Intratumoral pharmacokinetics: challenges to nanobiomaterials
AM Al-Abd, FA Al-Abbasi… - Current pharmaceutical …, 2015 - ingentaconnect.com
Resistance of solid tumors to treatment is significantly attributed to pharmacokinetic reasons
at both cellular and multi-cellular levels. Anticancer agent must be bio-available at the site of …
at both cellular and multi-cellular levels. Anticancer agent must be bio-available at the site of …
Noninvasive visualization of RNA delivery with 99mTc-radiolabeled small-interference RNA in tumor xenografts
L Kang, RF Wang, P Yan, M Liu, CL Zhang… - Journal of Nuclear …, 2010 - Soc Nuclear Med
Small-interference RNAs (siRNAs) are short, double-strand RNA molecules that target
specific messenger RNAs for degradation via the process termed RNA interference. The …
specific messenger RNAs for degradation via the process termed RNA interference. The …
Efficacy of systemically administered mutant vesicular stomatitis virus (VSVΔ51) combined with radiation for nasopharyngeal carcinoma
Purpose: Nasopharyngeal carcinoma (NPC) is a malignancy of the head and neck region
that is associated with EBV latency. Curative treatments for NPC achieve modest survival …
that is associated with EBV latency. Curative treatments for NPC achieve modest survival …
Enhanced vesicular stomatitis virus (VSVΔ51) targeting of head and neck cancer in combination with radiation therapy or ZD6126 vascular disrupting agent
Background Head and neck squamous cell carcinoma (HNSCC) is the 5th most common
cancer worldwide. Locally advanced HNSCC are treated with either radiation or chemo …
cancer worldwide. Locally advanced HNSCC are treated with either radiation or chemo …
Rapid obtention of stable, bioluminescent tumor cell lines using a tCD2-luciferase chimeric construct
AS Jimenez, M Gressette, C Barjon, M Wei… - BMC …, 2011 - Springer
Background Bioluminescent tumor cell lines are experimental tools of major importance for
cancer investigation, especially imaging of tumors in xenografted animals. Stable …
cancer investigation, especially imaging of tumors in xenografted animals. Stable …
[图书][B] Intratumoral pharmacokinetics and pharmacodynamics of gefitinib in an orthotopic brain tumor model
J Sharma - 2013 - search.proquest.com
Glioblastomas are highly vascular brain tumors that are characterized as heterogeneous,
comprised of an anatomically and functionally irregular blood brain barrier (BBB) that …
comprised of an anatomically and functionally irregular blood brain barrier (BBB) that …