From the biological point of view, bacterial biofilms are communities of bacteria embedded
in a self‐produced gel matrix composed of polysaccharides, DNA, and proteins. Considering …

The endogenous peptide kyotorphin (KTP) has been extensively studied since it was
discovered in 1979. The dipeptide is distributed unevenly over the brain but the majority is …

Objectives The selected kyotorphin derivatives were tested to improve their antimicrobial
and antibiofilm activity. The antimicrobial screening of the KTP derivatives were ascertained …

Kyotorphin (KTP, l-tyrosyl-l-arginine) is an endogenous dipeptide initially described to have
analgesic properties. Recently, KTP was suggested to be an endogenous neuroprotective …

Tyrosine-arginine (kyotorphin), an opioid analgesic dipeptide, was discovered more than 40
years ago in 1979. The evidence accumulated during this period has established the …

Abstract Kyotorphin (KTP) dipeptide (l-Tyrosine-l-Arginine) and their derivatives possess a
multitude of functions, qualifying them as" multifunctional peptides." Considering the …

Chronic brain ischemia is a prominent risk factor for neurological dysfunction and
progression for dementias, including Alzheimer's disease (AD). In rats, permanent bilateral …

Neuropeptide kyotorphin (KTP) is a potent analgesic if administered directly into the brain. In
contrast, KTP-amide (KTP-NH2) is analgesic, neuroprotective, and anti-inflammatory …

Kyotorphin (KTP) is an endogenous peptide with analgesic properties when administered
into the central nervous system (CNS). Its amidated form (l-Tyr-l-Arg-NH2; KTP-NH2) has …

Amidated kyotorphin (L-Tyr-L-Arg-NH2; KTP-NH2) shows analgesic properties following
systemic administration. Although KTP-NH2 does not have toxic effects in the liver, its …