[HTML][HTML] Functional polarization of tumor-associated macrophages dictated by metabolic reprogramming

W Zeng, F Li, S Jin, PC Ho, PS Liu, X Xie - Journal of Experimental & …, 2023 - Springer
Macrophages are highly plastic in different tissues and can differentiate into functional
subpopulations under different stimuli. Tumor-associated macrophages (TAMs) are one of …

[HTML][HTML] New insights into the role of adipocytes in pancreatic cancer progression: paving the way towards novel therapeutic targets

YC Lin, YC Hou, HC Wang, YS Shan - Theranostics, 2023 - ncbi.nlm.nih.gov
Pancreatic cancer (PC) remains one of the most lethal malignancies across the world, which
is due to delayed diagnosis and resistance to current therapies. The interactions between …

[HTML][HTML] Host obesity alters the ovarian tumor immune microenvironment and impacts response to standard of care chemotherapy

Y Liu, J Yang, TS Hilliard, Z Wang, J Johnson… - Journal of Experimental …, 2023 - Springer
Background The majority of women with epithelial ovarian cancer (OvCa) are diagnosed
with metastatic disease, resulting in a poor 5-year survival of 31%. Obesity is a recognized …

[HTML][HTML] Lipocalin-2 promotes adipose–macrophage interactions to shape peripheral and central inflammatory responses in experimental autoimmune …

F Sciarretta, V Ceci, M Tiberi, F Zaccaria, H Li… - Molecular …, 2023 - Elsevier
Objective Accumulating evidence suggests that dysfunctional adipose tissue (AT) plays a
major role in the risk of developing multiple sclerosis (MS), the most common immune …

[HTML][HTML] Outcomes in breast cancer—does ethnicity matter?

YS Yap - ESMO open, 2023 - Elsevier
Ethnic or racial differences in breast cancer (BC) survival outcomes have been reported, but
current data are largely restricted to comparisons between African Americans and non …

[HTML][HTML] Body mass index, C-reactive protein, and pancreatic cancer: A Mendelian randomization analysis to investigate causal pathways

Z Li, L Jin, L Xia, X Li, Y Guan, H He - Frontiers in Oncology, 2023 - frontiersin.org
Aim To explore whether C-reactive protein (CRP) mediates the risk of body mass index
(BMI) in pancreatic cancer (PC) and calculate the mediate proportion of CRP in this possible …

[HTML][HTML] Impact of intestinal microenvironments in obesity and bariatric surgery on shaping macrophages

M Leyderman, JR Wilmore, T Shope… - …, 2023 - journals.lww.com
Obesity is associated with alterations in tissue composition, systemic cellular metabolism,
and low-grade chronic inflammation. Macrophages are heterogenous innate immune cells …

A preliminary mechanistic exploration of the effect of leptin on the docetaxel sensitivity of MDA‑MB‑231 triple‑negative breast cancer cells

S Gao, S Ding, Z Tang - Molecular and Clinical …, 2024 - spandidos-publications.com
Breast cancer is a common tumor encountered in women, and triple‑negative breast cancer
(TNBC) has an extremely poor prognosis. The effect of leptin on the docetaxel sensitivity of …

Somatic evolution of Cancer: A new synthesis

U Baing, R Kharate, M Watve - 2023 - preprints.org
Cancers have been interpreted either as somatic evolution of cheater cells that escape
replication regulation or alternatively as non-healing wounds. Both the interpretations have …

[HTML][HTML] Obesity of children and adults-pandemic of the 21st century

D Panasiuk, P Szponarowicz, E Panek… - Journal of Education …, 2023 - apcz.umk.pl
Objective: The aim of the study was to draw attention to the problem of overweight and
obesity among children and adults. Another important aspect of this article was to indicate …