Progression of cerebral amyloid angiopathy: a pathophysiological framework

EA Koemans, JP Chhatwal, SJ van Veluw… - The Lancet …, 2023 - thelancet.com
Cerebral amyloid angiopathy, which is defined by cerebrovascular deposition of amyloid β,
is a common age-related small vessel pathology associated with intracerebral haemorrhage …

Multifaceted roles of APOE in Alzheimer disease

RJ Jackson, BT Hyman, A Serrano-Pozo - Nature Reviews Neurology, 2024 - nature.com
For the past three decades, apolipoprotein E (APOE) has been known as the single greatest
genetic modulator of sporadic Alzheimer disease (AD) risk, influencing both the average age …

Machine learning: new ideas and tools in environmental science and engineering

S Zhong, K Zhang, M Bagheri, JG Burken… - … science & technology, 2021 - ACS Publications
The rapid increase in both the quantity and complexity of data that are being generated daily
in the field of environmental science and engineering (ESE) demands accompanied …

Blood-brain barrier dysfunction in normal aging and neurodegeneration: mechanisms, impact, and treatments

AV Andjelkovic, M Situ, AF Citalan-Madrid… - Stroke, 2023 - Am Heart Assoc
Cerebral endothelial cells and their linking tight junctions form a unique, dynamic and multi-
functional interface, the blood-brain barrier (BBB). The endothelium is regulated by …

A practical approach to the management of cerebral amyloid angiopathy

MG Kozberg, V Perosa, ME Gurol… - … Journal of Stroke, 2021 - journals.sagepub.com
Cerebral amyloid angiopathy is a common small vessel disease in the elderly involving
vascular amyloid-β deposition. Cerebral amyloid angiopathy is one of the leading causes of …

Neuropathological correlates of cortical superficial siderosis in cerebral amyloid angiopathy

A Charidimou, V Perosa, MP Frosch, AA Scherlek… - Brain, 2020 - academic.oup.com
Cortical superficial siderosis is an established haemorrhagic neuroimaging marker of
cerebral amyloid angiopathy. In fact, cortical superficial siderosis is emerging as a strong …

Clinical considerations in early-onset cerebral amyloid angiopathy

G Banerjee, J Collinge, NC Fox, T Lashley, S Mead… - Brain, 2023 - academic.oup.com
Cerebral amyloid angiopathy (CAA) is an important cerebral small vessel disease
associated with brain haemorrhage and cognitive change. The commonest form, sporadic …

Vessels sing their ARIAs: the role of vascular amyloid in the age of aducanumab

L Sveikata, A Charidimou, A Viswanathan - Stroke, 2022 - Am Heart Assoc
We review the implications of the recently approved aducanumab amyloid-β immunotherapy
for treating Alzheimer disease with comorbid cerebral amyloid angiopathy. In clinical trials …

Relationship of apolipoprotein E with Alzheimer's disease and other neurological disorders: an updated review

T Lou, B Tao, M Chen - Neuroscience, 2023 - Elsevier
Alzheimer's disease (AD) and other neurodegenerative diseases, for which there is no
effective cure, cause great social burden. Apolipoprotein E (APOE) is an important lipid …

[HTML][HTML] Genetic architecture of common non-Alzheimer's disease dementias

R Guerreiro, E Gibbons, M Tábuas-Pereira… - Neurobiology of …, 2020 - Elsevier
Frontotemporal dementia (FTD), dementia with Lewy bodies (DLB) and vascular dementia
(VaD) are the most common forms of dementia after Alzheimer's disease (AD). The …