Despite the ubiquity of transbilayer asymmetry in natural cell membranes, the vast majority
of existing research has utilized chemically well-defined symmetric liposomes, where the …

Lipids rafts are considered to be functional nanoscale membrane domains enriched in
cholesterol and sphingolipids, characteristic in particular of the external leaflet of cell …

Understanding how functional lipid domains in live cell membranes are generated has
posed a challenge. Here, we show that transbilayer interactions are necessary for the …

Cell membranes are complex multicomponent systems, which are highly heterogeneous in
the lipid distribution and composition. To date, most molecular simulations have focussed on …

The transverse asymmetry (sidedness) of phospholipids in plasma membrane bilayers is
well characterized, distinctive, actively maintained and functionally important. In contrast …

There is great diversity in the composition and structure of biological lipid membranes. We
are beginning to appreciate the crucial role of lipids in many cellular processes, and …

The compositional asymmetry of biological membranes has attracted significant attention
over the last decade. Harboring more differences from symmetric membranes than …

Simplified lipid mixtures are often used to model the complex behavior of the cell plasma
membrane. Indeed, as few as four components a high-melting lipid, a nandomain-inducing …

Lipid membranes in prokaryotes and eukaryotes have a wide array of lipids that are
necessary for proper membrane structure and function. In this paper, an introduction to lipid …

Recent studies indicate that there are mechanical differences between normal cells and
cancer cells. Because the cell membrane takes part in a variety of vital processes, we test …